752235-38-4

Upstream product

• 15344-34-0 2-hydroxy-3-methylbutanenitrile 
• 752235-28-2 3-benzyloxy-5-isopropyl-oxazolidin-2,4-dione 

Relevant academic research and scientific papers

Highly Efficient DMSO-Promoted α-Hydrolysis of α-Halohydroxamates under Mild Conditions

A novel and efficient method for the nucleophilic α-hydrolysis of α-halohydroxamates with water under metal-free conditions is described. In this reaction, the simple and readily available dimethyl sulfoxide (DMSO) was used as a catalyst, while water serv

O-Protected 3-hydroxy-oxazolidin-2,4-diones: Novel precursors in the synthesis of α-hydroxyhydroxamic acids

O-Protected 3-hydroxyoxazolidin-2,4-diones have been prepared in a novel one-pot reaction by subsequent treatment of cyanohydrins with 1,1′-carbonyldiimidazole and O-protected hydroxylamines followed by acidic hydrolysis of the intermediate 4-imino-oxazolidin-2-ones. Decarbonylation of O-protected 3-hydroxyoxazolidin-2,4-diones by catalytic amounts of sodium methoxide, lithium hydroxide, sodium carbonate and caesium carbonate in methanol afforded O-protected α-hydroxyhydroxamic acids in excellent yields. Their deprotection provided a series of novel α-hydroxyhydroxamic acids.