752251-02-8

Upstream product

• 30033-24-0 (2S)-3-(3,4-dihydroxyphenyl)-2-[(tert-butoxy)carbonylamino]propanoic acid 
• 124-40-3 dimethyl amine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 59-92-7 levodopa 
• 109-89-7 diethylamine 

Downstream Products

• 823235-81-0 (2S)-[2-(3,4-bis-benzyloxy-phenyl)-1-dimethylcarbamoyl-ethyl]-carbamic acid tert-butyl ester 
• 752251-06-2 (S)-3-amino-6,7-bis(OBn)-1,1-dimethyl-1,2,3,4-tetrahydroquinolin-1-ium L-ser(OBn)-D-ser (OBn)-BocL-thr(OBn) 
• 752251-07-3 H-L-Thr(OBn)-D-Ser(OBn)-LSer(OBn)-(3S)-THQ(OBn) 
• 752251-05-1 (2S,3S)-6,7-bis-benzyloxy-3-(3-benzyloxy-2-tert-butoxycarbonylaminopropionylamino)-1,1-dimethyl-1,2,3,4-tetrahydroquinolinium 
• 752251-19-7 (S)-3-((S)-2-Amino-3-benzyloxy-propionylamino)-6,7-bis-benzyloxy-1,1-dimethyl-1,2,3,4-tetrahydro-quinolinium 
• 752251-00-6 (2S,3S)-3-(3-benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-quinolinium 
• 752251-04-0 (S,S)-{2-benzyloxy-1-[1-(3,4-dihydroxy-benzyl)-2-dimethylamino-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 862695-37-2 4-((S)-2-Amino-3-dimethylamino-propyl)-benzene-1,2-diol 
• 752251-03-9 (S)-[1-(3,4-dihydroxy-benzyl)-2-dimethylamino-ethyl]-carbamic acid tert-butyl ester 
• 823235-82-1 (2S)-[2-(3,4-bis-benzyloxyphenyl)-1-(dimethylaminomethyl)ethyl]carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

An alternative approach to the synthesis of the three fragments of anachelin H

The synthesis of the fully protected peptide, polyketide and alkaloid fragments of anachelin H is presented. The peptide fragment was prepared using a liquid phase peptide synthesis; the polyketide fragment was synthetized using a cross metathesis and an intramolecular oxa-Michael reaction as the key steps to introduce the desired stereochemistry; finally, the alkaloid fragment was obtained by an oxidative cyclization of a catechol derivative using potassium ferricyanide. The synthesis of all fragments was based on the use of natural amino acids as sources of asymmetry. The independent synthesis of the three fragments should allow more efficient biological studies on the fragments instead of the whole natural product. Experiments to illustrate the coupling of fragments and the effectiveness of the convergent strategy are also described.

Protein-resistant surfaces through mild dopamine surface functionalization

The synthesis and evaluation of new dopamine-based catechol anchors coupled to poly(ethylene glycol) (PEG) for surface modification of TiO2 are reported. Dopamine is modified by dimethylamine-methylene (7) or trimethylammonium-methylene (8) groups, and the preparation of mPEG-Glu di-dopamine polymer 11 is presented. All these PEG polymers allow stable adlayers on TiO2 to be generated through mild dip-and-rinse procedures, as evaluated both by variable angle spectroscopic ellipsometry and X-ray photoelectron spectroscopy. The resulting surfaces substantially reduced protein adsorption upon exposure to full human serum.

A biomimetic route to the peptide alkaloid anachelin

A postulated biogenesis forms the basis for a synthetic route to the natural product anachelin H (1). Key steps include a tellurium-mediated, oxidative aza annulation and a Claisen condensation under mild conditions. Experiments with a model substrate ind