7526-70-7

Usage

Type of compound

Phosphine ligand

Application

Organic synthesis and coordination chemistry

Usage

Commonly used as a ligand in transition metal-catalyzed reactions

Specificity

Particularly effective in the formation of carbon-carbon and carbon-heteroatom bonds

Structural feature

Bulky and electron-donating nature

Versatility

Highly versatile and effective ligand in various catalytic processes

Industry application

Pharmaceutical industry

Role in pharmaceuticals

Synthesis of pharmaceutical intermediates

Known for

High efficiency and selectivity in a wide range of chemical transformations

Upstream product

• 109-99-9 tetrahydrofuran 
• 603-35-0 triphenylphosphine 
• 829-85-6 diphenylphosphane 
• 5011-33-6 2,2-di(chloromethyl)-1-methoxypropane 
• 201230-82-2 carbon monoxide 
• 2741-38-0 allyldiphenylphosphine 
• 33036-62-3 4-Bromo-1-butanol 
• 1079-66-9 chloro-diphenylphosphine 

Downstream Products

• 113705-06-9 1,1-Diphenyl-3,4-dihydro-2H-1λ⁵-phosphole 
• 222641-62-5 (4-hydroxybutyl)(diphenyl)phosphine sulfide 
• 343952-60-3 (C₆H₅)2P(CH₂)4P(C₆H₄OCH₃)2 
• 343952-61-4 (C₆H₅)2P(CH₂)4P(C₆H₁₁)2 
• 343952-59-0 (C₆H₅)2P(CH₂)4P(C₆H₃(CH₃)2)2 
• 175345-44-5 Ni(CO)3((C₆H₅)2P(CH₂)4OH) 
• 222641-63-6 (4-bromobutyl)(diphenyl)phosphine sulfide 
• 55759-75-6 1,1-diphenylphospholanium perchlorate 

Relevant academic research and scientific papers

Ring-Chain Halotropic Tautomerism. Synthesis and Mutual Conversions of 2,2-Diphenyl-1,2λ4-thiaphosphorinanium Bromide and 4-Bromobutyldiphenylphosphine Sulfide

The isomeric 2,2-diphenyl-1,2λ4-thiaphosphorinanium bromide and 4-bromobutyldiphenylphosphine sulfide were isolated individual. In solutions the cyclic and linear isomers are in equilibrium, i.e. a ring-chain anionotropic tautomerism takes plac

A remarkably simple process for monoprotecting diols

Lipase from pig pancreas (PPL) has been shown to catalyse selectively the hydrolysis of alkane-1,n-diol bis-acetates into the corresponding monoacetate.

The Stereochemistry of Organometallic Compounds. XXXVII. Regio- and Stereo-control in the Rhodium-Catalysed Hydroformylation of Some Alkenylphosphines

Good to excellent regiocontrol can be obtained for the internal product of rhodium-catalysed hydroformylation of a range of alkenylphosphines.Excellent stereo- as well as regio-control can also be obtained for reactions of some cyclic alkenylphosphines.

UNUSUAL TRIPOD-LIKE LIGANDS. SYNTHESIS OF 2,2-BIS(DIPHENYLPHOSPHINOMETHYL)-1-METHOXYPROPANE AND 2,2-BIS(PHENYLTHIOMETHYL)-1-METHOXYPROPANE

By employment of 1,1,1-tris(hydroxymethyl)ethane as the starting material, syntheses of two novel tripod-like terdentates with mixed donor properties, 2,2-Bis(diphenylphosphinomethyl)-1-methoxypropane (P2O) and 2,2-Bis(diphenylphosphinomethyl)-1-methoxypropane (S2O) are reported.Structural confirmation is based on spectroscopic and analytical results.Key words: tripodal ligands; terdentates; organophosphine ligand; organosulfur ligand.

Chelation Control in the Hydroformylation of Terminal Alkenes

Hydroformylation of phosphine-bearing terminal alkenes can lead to a complete reversal of regioselection to that observed for simpler alkenes.