75268-14-3

Basic information

• Product Name: 4-hydroxy-N-(2-hydroxyethyl)benzamide
• Synonyms: 4-hydroxy-N-(2-hydroxyethyl)benzamide
• CAS NO: 75268-14-3
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.19
• Mol File: 75268-14-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 451.2°C at 760 mmHg
• Flash Point: 226.7°C
• Appearance: /
• Density: 1.273g/cm³
• Vapor Pressure: 6.28E-09mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 4-hydroxy-N-(2-hydroxyethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-N-(2-hydroxyethyl)benzamide(75268-14-3)
• EPA Substance Registry System: 4-hydroxy-N-(2-hydroxyethyl)benzamide(75268-14-3)

Safety Data

• Hazardous Substances Data: 75268-14-3(Hazardous Substances Data)

Usage

General Description

4-hydroxy-N-(2-hydroxyethyl)benzamide, also known as N-(2-hydroxyethyl)-p-hydroxybenzamide, is a chemical compound with the molecular formula C9H9NO3. It is a white crystalline solid that is sparingly soluble in water. 4-hydroxy-N-(2-hydroxyethyl)benzamide is often used as a pharmaceutical intermediate and is also a key ingredient in the production of various drugs and compounds. Additionally, it is known for its antioxidant properties and has been studied for its potential therapeutic effects, particularly in the field of dermatology. However, it is important to handle this chemical with care, as it may pose risks to human health and the environment if not used properly or disposed of safely.

InChI:InChI=1/C9H11NO3/c11-6-5-10-9(13)7-1-3-8(12)4-2-7/h1-4,11-12H,5-6H2,(H,10,13)

Upstream product

• 141-43-5 ethanolamine 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 99-96-7 4-hydroxy-benzoic acid 
• 28141-24-4 4-hydroxybenzoyl chloride 

Downstream Products

• 98033-95-5 5-{4-[4-(4,5-dihydro-2-oxazolyl)phenoxy]butyl}-3-methylisoxazole 
• 98033-91-1 5-{8-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]octyl}-3-methylisoxazole 
• 98033-84-2 5-{6-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]hexyl}-3-methylisoxazole 
• 98034-30-1 5-(5-(4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-methylisoxazole 
• 81428-58-2 4-(4,5-dihydro-2-oxazolyl)phenol 
• 93472-62-9 4,5-dihydro-2-(4-hydroxyphenyl)oxazole hydrochloride 

Relevant articles and documents

TASTE-MODIFYING COMPOUNDS AND USES THEREOF

The present disclosure generally relates to compounds useful as taste modifiers, particularly as compounds useful for enhancing umami taste, and their use in various comestible products, such as food and beverage products.

OXAZOLINE COMPOUND, CROSSLINKING AGENT AND RESIN COMPOSITION

PROBLEM TO BE SOLVED: To provide an oxazoline compound optimal as a crosslinking agent in a wide range of applications such as a coating agent, ink, a film, a binder and an adhesive. SOLUTION: There are provided an oxazoline compound represented by the following chemical formula, and a crosslinking agent and a resin composition using the oxazoline compound. In the formula, X is a group having a carbon-carbon double bond, and is a group containing an acrylic group or a methacrylic group. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Three isomeric forms of hydroxyphenyl-2-oxazoline: 2-(2-hydroxyphenyl)-2- oxazoline, 2-(3-hydroxyphenyl)-2-oxazoline and 2-(4-hydroxyphenyl)-2-oxazoline

Crystal structures are reported for three isomeric compounds, namely 2-(2-hydroxyphenyl)-2-oxazoline, (I), 2-(3-hydroxyphenyl)-2-oxazoline, (II), and 2-(4-hydroxyphenyl)-2-oxazoline, (III), all C9H9NO 2 [systematic names: 2-(4,5-dihydro-1,3-oxazol-2-yl)phenol, (I), 3-(4,5-dihydro-1,3-oxazol-2-yl)phenol, (II), and 4-(4,5-dihydro-1,3-oxazol-2-yl) phenol, (III)]. In these compounds, the deviation from coplanarity of the oxazoline and benzene rings is dependent on the position of the hydroxy group on the benzene ring. The coplanar arrangement in (I) is stabilized by a strong intramolecular O-H...N hydrogen bond. Surprisingly, the 2-oxazoline ring in molecule B of (II) adopts a 3T4 (C2T C3) conformation, while the 2-oxazoline ring in molecule A, as well as that in (I) and (III), is nearly planar, as expected. Tetramers of molecules of (II) are formed and they are bound together via weak C-H...N hydrogen bonds. In (III), strong intermolecular O-H...N hydrogen bonds and weak intramolecular C-H...O hydrogen bonds lead to the formation of an infinite chain of molecules perpendicular to the b direction. This paper also reports a theoretical investigation of hydrogen bonds, based on density functional theory (DFT) employing periodic boundary conditions.