75268-14-3

Usage

Uses

Used in Pharmaceutical Industry:
4-hydroxy-N-(2-hydroxyethyl)benzamide is used as a pharmaceutical intermediate for the synthesis of various drugs and compounds. Its unique chemical structure allows it to be a versatile building block in the development of new medications.
Used in Dermatology:
4-hydroxy-N-(2-hydroxyethyl)benzamide is used as a key ingredient in dermatological applications due to its antioxidant properties. It has been studied for its potential therapeutic effects in treating various skin conditions and promoting skin health.
Used in Antioxidant Formulations:
Due to its antioxidant properties, 4-hydroxy-N-(2-hydroxyethyl)benzamide is used in the formulation of various antioxidant products. These products can help protect cells from oxidative damage and may have potential applications in the prevention and treatment of various diseases and conditions related to oxidative stress.

InChI:InChI=1/C9H11NO3/c11-6-5-10-9(13)7-1-3-8(12)4-2-7/h1-4,11-12H,5-6H2,(H,10,13)

Upstream product

• 141-43-5 ethanolamine 
• 99-96-7 4-hydroxy-benzoic acid 
• 28141-24-4 4-hydroxybenzoyl chloride 
• 99-76-3 methyl 4-hydroxylbenzoate 

Downstream Products

• 93472-62-9 4,5-dihydro-2-(4-hydroxyphenyl)oxazole hydrochloride 
• 81428-58-2 4-(4,5-dihydro-2-oxazolyl)phenol 
• 98034-30-1 5-(5-(4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-methylisoxazole 
• 98033-95-5 5-{4-[4-(4,5-dihydro-2-oxazolyl)phenoxy]butyl}-3-methylisoxazole 
• 98033-91-1 5-{8-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]octyl}-3-methylisoxazole 
• 98033-84-2 5-{6-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]hexyl}-3-methylisoxazole 

Relevant academic research and scientific papers

TASTE-MODIFYING COMPOUNDS AND USES THEREOF

The present disclosure generally relates to compounds useful as taste modifiers, particularly as compounds useful for enhancing umami taste, and their use in various comestible products, such as food and beverage products.

OXAZOLINE COMPOUND, CROSSLINKER AND RESIN COMPOSITION

PROBLEM TO BE SOLVED: To provide an oxazoline compound and trioxazoline compound optimal as crosslinkers for a wide range of uses, including a coating agent, ink, a film, a binder, and adhesive or the like. SOLUTION: The present invention provides an oxazoline compound represented by the following chemical formula, a trioxazoline compound obtained by trifunctionalizing the oxazoline compound represented by the following chemical formula, and a crosslinker and a resin composition using the oxazoline compound or the trioxazoline compound. In the formula, X is H or R-OH, R is a C1-4 linear or branched alkylene group. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPO&INPIT

OXAZOLINE COMPOUND, CROSSLINKING AGENT AND RESIN COMPOSITION

PROBLEM TO BE SOLVED: To provide an oxazoline compound optimal as a crosslinking agent in a wide range of applications such as a coating agent, ink, a film, a binder and an adhesive. SOLUTION: There are provided an oxazoline compound represented by the following chemical formula, and a crosslinking agent and a resin composition using the oxazoline compound. In the formula, X is a group having a carbon-carbon double bond, and is a group containing an acrylic group or a methacrylic group. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Design, synthesis and biological activity evaluation of a new class of 2,4-thiazolidinedione compounds as insulin enhancers

Diabetes mellitus (DM) is a global disease with a high incidence of type 2 diabetes. Current studies have shown that insulin enhancers play an important role in the treatment of type 2 diabetes and have great importance in the improvement of type 2 diabetes. In this research, Rosiglitazone was taken as the lead compound, and the structure was modified by using the bioisostere principle, and a new class of 2,4-thiazolanedione compound was designed and synthesised. The novel series of compounds were studied for their biological activities in vitro and in vivo. In vitro tests, the biological activities showed that the target compounds have good selective activation of peroxisome-proliferator-activated receptor γ (PPARγ), such as the compounds 6a, 6e, 6f, 6g and 6i, especially the compound 6e to PPARγ was EC50 = 0.03 ± 0.01 μmol/L in vitro. Then, in vivo biological activities’ test results showed that the tendency of increasing in blood sugar had an obvious inhibiting effect, and had a significant insulin hypoglycaemic effect of enhancing and extending the exogenous. In addition, the results of cytotoxicity tests and acute toxicity tests (LD50) showed that these compounds belong to the low toxicity compounds.

Three isomeric forms of hydroxyphenyl-2-oxazoline: 2-(2-hydroxyphenyl)-2- oxazoline, 2-(3-hydroxyphenyl)-2-oxazoline and 2-(4-hydroxyphenyl)-2-oxazoline

Crystal structures are reported for three isomeric compounds, namely 2-(2-hydroxyphenyl)-2-oxazoline, (I), 2-(3-hydroxyphenyl)-2-oxazoline, (II), and 2-(4-hydroxyphenyl)-2-oxazoline, (III), all C9H9NO 2 [systematic names: 2-(4,5-dihydro-1,3-oxazol-2-yl)phenol, (I), 3-(4,5-dihydro-1,3-oxazol-2-yl)phenol, (II), and 4-(4,5-dihydro-1,3-oxazol-2-yl) phenol, (III)]. In these compounds, the deviation from coplanarity of the oxazoline and benzene rings is dependent on the position of the hydroxy group on the benzene ring. The coplanar arrangement in (I) is stabilized by a strong intramolecular O-H...N hydrogen bond. Surprisingly, the 2-oxazoline ring in molecule B of (II) adopts a 3T4 (C2T C3) conformation, while the 2-oxazoline ring in molecule A, as well as that in (I) and (III), is nearly planar, as expected. Tetramers of molecules of (II) are formed and they are bound together via weak C-H...N hydrogen bonds. In (III), strong intermolecular O-H...N hydrogen bonds and weak intramolecular C-H...O hydrogen bonds lead to the formation of an infinite chain of molecules perpendicular to the b direction. This paper also reports a theoretical investigation of hydrogen bonds, based on density functional theory (DFT) employing periodic boundary conditions.

Synthesis and Structure-Activity Studies of Some Disubstituted Phenylisoxazoles against Human Picornavirus

A number 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated against several rhinovirus serotypes.A QSAR study revealed that the mean MIC () against five rhinovirus serotypes correlated well with log P.The 2,6-dichloro analogue, 15, was highly effective in vitro against rhinoviruses with an MIC80 of 0.3 μM, as well as against several enteroviruses, and was also effective in preventing paralysis in mice infected with coxsackievirus A-9.

Di-heterocyclic compounds and their use as antiviral agents

Compounds of the formulas: STR1 wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed.

Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents

Compounds of the formula STR1 wherein the substituents are as defined herein are useful as antiviral agents, in particular against picornaviruses.