98034-30-1Relevant academic research and scientific papers
Di-heterocyclic compounds and their use as antiviral agents
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, (2008/06/13)
Compounds of the formulas: STR1 wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed.
Synthesis and Structure-Activity Studies of Some Disubstituted Phenylisoxazoles against Human Picornavirus
Diana, Guy D.,Cutcliffe, David,Oglesby, Richard C.,Otto, Michael J.,Mallamo, John P.,et al.
, p. 450 - 455 (2007/10/02)
A number 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated against several rhinovirus serotypes.A QSAR study revealed that the mean MIC () against five rhinovirus serotypes correlated well with log P.The 2,6-dichloro analogue, 15, was highly effective in vitro against rhinoviruses with an MIC80 of 0.3 μM, as well as against several enteroviruses, and was also effective in preventing paralysis in mice infected with coxsackievirus A-9.
Structure-Activity Studies of 5-alkyl>-3-methylisoxazoles: Inhibitors of Picornavirus Uncoating
Diana, Guy D.,Oglesby, Richard C.,Akullian, Vahan,Carabateas, Phillip M.,Cutcliffe, David,et al.
, p. 383 - 388 (2007/10/02)
A series of substituted phenyl analogues of 5-alkyl>-3-methylisoxazoles has been synthesized and evaluated in vitro against several human rhinovirus (HRV) serotypes.Substituents in the 2-position greatly enhanced activi
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating
Diana,McKinlay,Otto,Akullian,Oglesby
, p. 1906 - 1910 (2007/10/02)
A series of [[(4,5-dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles has been synthesized and evaluated as antipicornavirus agents. The effect of alkyl groups in the 4- and 5-position of the oxazoline ring, as well as the alkyl chain length, on antiviral activi
