75288-12-9Relevant academic research and scientific papers
Efficient synthesis of N-methylamides and amines via 4-(alkylamino)benzyl- N-methylamine as a new protecting group
Lee, Sang-Hak,Mu, Yu,Kim, Gun-Woo,Kim, Jin-Seok,Park, Seok-Hwi,Jin, Tian,Lee, Kee-Young,Ham, Won-Hun
, p. 1749 - 1764 (2013/09/12)
4-(Alkylamino)benzyl-N-methylamine is a good protecting group for the synthesis of N-methylamides and amines. The N-debenzylation of N-methylamides and amines can be carried out selectively and efficiently under condition using trifluoroacetic acid (TFA).
N-Alkylamidomethylation at Electron-rich Carbons in the 1,3,5-Trialkylhexahydro-1,3,5-triazine-Acetyl Chloride System
Ikeda, Kiyoshi,Morimoto, Toshiaki,Sekiya, Minoru
, p. 1178 - 1182 (2007/10/02)
A new N-alkylamidomethylation reaction at electron-rich carbons has been developed using 1,3,5-trialkylhexahydro-1,3,5-triazine in the presence of acetyl chloride.This reaction was carried out not only with aromatics such as phenols, alkoxybenzenes and aromatic amines, but also olefins such as styrene and vinyl ethers. Keywords---N-alkylamidomethylation; electrophilic substitution; 1,3,5-trialkylhexahydro-1,3,5-triazines; acetyl chloride; aromatics; styrene; vinyl ethers
