7529-87-5

Usage

Uses

Used in Coatings Industry:
Monoisopropyl fumarate is used as a crosslinking agent for improving the flexibility, durability, and mechanical properties of coatings. It helps in enhancing the performance and longevity of the coatings applied to various surfaces.
Used in Adhesives Industry:
In the adhesives industry, monoisopropyl fumarate serves as a crosslinking agent, contributing to the improved adhesion strength, flexibility, and durability of adhesive formulations. It ensures better bonding and performance of adhesives in various applications.
Used in Resins Industry:
Monoisopropyl fumarate is used as a crosslinking agent in the production of resins, enhancing their flexibility, durability, and mechanical properties. This results in improved performance and stability of resins in a wide range of applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, monoisopropyl fumarate is used as an intermediate in the synthesis of various drugs. Its unique chemical properties make it a valuable component in the development of new and effective medications.
Used in Food Packaging Materials:
Monoisopropyl fumarate is used as a stabilizer and antioxidant in food packaging materials. It helps in preserving the quality and freshness of packaged food products by preventing oxidation and degradation, thereby extending their shelf life.

InChI:InChI=1/C7H10O4/c1-5(2)11-7(10)4-3-6(8)9/h3-5H,1-2H3,(H,8,9)/b4-3+

Upstream product

• 93606-08-7 Isopropyl (E)-3-formylpropenoate 
• 108-31-6 maleic anhydride 
• 110-17-8 (2E)-but-2-enedioic acid 
• 67-63-0 isopropyl alcohol 

Relevant academic research and scientific papers

Kras-G12C inhibitor heterocyclic compounds

The invention relates to Kras-G12C inhibitor heterocyclic compounds represented by formula I, a preparation method thereof, and application of the Kras-G12C inhibitor heterocyclic compounds in prevention and treatment of tumor diseases such as lung cancer, colorectal cancer and pancreatic cancer. In the preparation process, the compounds of the general formula I are obtained through a series of reactions such as SN2 reaction, protection, coupling reaction, deprotection, condensation reaction and the like.

Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A)

Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids and esters such as methyl fumarate also interact with the receptor, which constituted the basis for the current study. We synthesized a novel series of substituted propenoic acids, such as fumaric acid esters, fumaric acid amides and cinnamic acid derivatives, and determined their affinities for the HCA2 receptor. We observed a rather restricted binding pocket on the receptor with trans-cinnamic acid being the largest planar ligand in our series with appreciable affinity for the receptor. Molecular modeling and analysis of the structure-activity relationships in the series suggest a planar trans-propenoic acid pharmacophore with a maximum length of 8 ? and out-of-plane orientation of the larger substituents.

Fumaric acid derivative and polymer therefrom

A polymer obtained by polymerizing a fumaric acid derivative represented by the following general formula (1): STR1 in which R1 represents an alkyl group having 1-6 carbon atoms and A denotes a radical of STR2 in which R2 and R3 represent each an alkyl group having 1-4 carbon atoms and may be identical with or different from each other, R4 denotes an alkyl group having 1-6 carbon atoms or a benzyl group and m and n denote each an integer of 1-6.

Process for the preparation of fumaric acid monoesters

Fumaric acid monoesters can be prepared by introducing a hydroxyl compound at a rate corresponding to the progress of the reaction into a solution or a melt of maleic anhydride, which may optionally be substituted, if appropriate in the presence of a cis-trans catalyst. New fumaric acid monoesters can be formed by the process.