753000-66-7Relevant academic research and scientific papers
A Simple and efficient route to chaetomellic anhydride A: A potent natural ras farnesyl-protein transferase inhibitor
De Buyck, Laurent,Cagnoli, Rita,Ghelfi, Franco,Merighi, Giulia,Mucci, Adele,Pagnoni, Ugo M.,Parsons, Andrew F.
, p. 1680 - 1686 (2004)
A new and efficient approach to chaetomellic anhydride A has been devised starting from 2,2-dichloropalmitic acid. This involves the atom transfer radical cyclization of an N-alkyl-N-(3-chloro-2-propenyl)amide followed by rearrangement of the resulting trichloro-pyrrolidin-2-one.
