75318-49-9Relevant articles and documents
1,2,3-Dithiazoles-new reversible melanin synthesis inhibitors: A chemical genomics study
Charalambous, Anna,Koyioni, Maria,Antoniades, Ioanna,Pegeioti, Despoina,Eleftheriou, Iro,Michaelidou, Sophia S.,Amelichev, Stanislav A.,Konstantinova, Lidia S.,Rakitin, Oleg A.,Koutentis, Panayiotis A.,Skourides, Paris A.
, p. 935 - 946 (2015)
A chemical genomic screen of an in-house library of small molecule heterocycles was carried out using Xenopus laevis embryos. This led to the identification of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methoxyaniline (1c), which elicits loss of pigmenta
Rapid and scalable assembly of firefly luciferase substrates
McCutcheon, David C.,Porterfield, William B.,Prescher, Jennifer A.
supporting information, p. 2117 - 2121 (2015/03/18)
Bioluminescence imaging with luciferase-luciferin pairs is a popular method for visualizing biological processes in vivo. Unfortunately, most luciferins are difficult to access and remain prohibitively expensive for some imaging applications. Here we report cost-effective and efficient syntheses of d-luciferin and 6′-aminoluciferin, two widely used bioluminescent substrates. Our approach employs inexpensive anilines and Appel's salt to generate the luciferin cores in a single pot. Additionally, the syntheses are scalable and can provide multi-gram quantities of both substrates. The streamlined production and improved accessibility of luciferin reagents will bolster in vivo imaging efforts. This journal is
Antibacterial evaluation of novel N-arylimino-1,2,3-dithiazoles and N-arylcyanothioformamides
Cottenceau, Gilles,Besson, Thierry,Gautier, Valerie,Rees, Charles W.,Pons, Anne-Marie
, p. 529 - 532 (2007/10/03)
N-Aryl-1,2,3-dithiazoles 2 and the corresponding N-arylcyanothioformamides 3 have been synthesized via 4,5-dichloro-1,2,3-dithiazole derivatives, and their antibacterial activity measured; the dithiazoles are significantly active against Gram-positive bacteria.
