75319-01-6

Upstream product

• 6245-57-4 4-methoxy-2-methylbenzoic acid 
• 31310-08-4 2-methyl-4-methoxybenzoyl chloride 

Downstream Products

• 75318-83-1 3-(4-Methoxy-2-methyl-phenyl)-5-(3-methoxy-phenyl)-1H-[1,2,4]triazole 
• 85303-97-5 3-(4-Methoxy-2-methyl-phenyl)-5-phenyl-1H-[1,2,4]triazole 

Relevant academic research and scientific papers

A New Class of Nonhormonal Pregnancy-Terminating Agents. Synthesis and Contragestational Activity of 3,5-Diaryl-s-triazoles

A series of 3,5-diaryl-s-triazoles were synthesized and evaluated as postimplantation contragestational agents.The introduction of various substituents (e.g., an o-alkyl chain on one phenyl and a m-alkoxy group on the other) was found to increase the potency.Several compounds with very high pregnancy-terminating activity in both hamsters and rats were obtained.One of these, 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-s-triazole, DL 111 (36), was selected for detailed evaluation in various animal species.A synthetic scheme for the preparation of these compounds and preliminary structure-activity relationships are presented.