85303-97-5

Usage

Molecular weight

250.29 g/mol

Class

Phenyl-1,2,4-triazoles (heterocyclic compounds containing a 1,2,4-triazole substituted by a phenyl group)

Appearance

White solid

Melting point

140-143°C

Uses

Building block for the synthesis of various bioactive molecules, including potential drug candidates in medicinal chemistry and pharmaceutical research

Potential biological activities

Anti-cancer and anti-inflammatory properties.

Upstream product

• 75319-01-6 4-methoxy-2-methylbenzoic acid hydrazide 
• 6245-57-4 4-methoxy-2-methylbenzoic acid 
• 31310-08-4 2-methyl-4-methoxybenzoyl chloride 

Relevant academic research and scientific papers

A New Class of Nonhormonal Pregnancy-Terminating Agents. Synthesis and Contragestational Activity of 3,5-Diaryl-s-triazoles

A series of 3,5-diaryl-s-triazoles were synthesized and evaluated as postimplantation contragestational agents.The introduction of various substituents (e.g., an o-alkyl chain on one phenyl and a m-alkoxy group on the other) was found to increase the potency.Several compounds with very high pregnancy-terminating activity in both hamsters and rats were obtained.One of these, 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-s-triazole, DL 111 (36), was selected for detailed evaluation in various animal species.A synthetic scheme for the preparation of these compounds and preliminary structure-activity relationships are presented.