75343-75-8

Basic information

• Product Name: 3-CHLOROPHENYL-(2-PYRIDYL)METHANOL
• Synonyms: 3-CHLOROPHENYL-(2-PYRIDYL)METHANOL
• CAS NO: 75343-75-8
• Molecular Formula: C₁₂H₁₀ClNO
• Molecular Weight: 219.67
• Mol File: 75343-75-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-CHLOROPHENYL-(2-PYRIDYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLOROPHENYL-(2-PYRIDYL)METHANOL(75343-75-8)
• EPA Substance Registry System: 3-CHLOROPHENYL-(2-PYRIDYL)METHANOL(75343-75-8)

Safety Data

• Hazardous Substances Data: 75343-75-8(Hazardous Substances Data)

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 36229-42-2 (3-chlorophenyl)magnesium bromide 
• 108-37-2 1-bromo-3-chlorobenzene 
• 73742-07-1 (3-chlorophenyl)(pyridin-2-yl)methanone 
• 100-70-9 2-Cyanopyridine 

Downstream Products

• 58294-14-7 2-(3-chlorobenzyl)pyridine 
• 928046-28-0 1-(3-chlorophenyl)-3-methyl-1-(2-pyridyl)-1-butanol 
• 928046-51-9 2-[1-(3-chlorophenyl)-3-methyl-1-butenyl]pyridine 
• 73742-07-1 (3-chlorophenyl)(pyridin-2-yl)methanone 
• 75343-85-0 (3-Chloro-phenyl)-piperidin-2-yl-methanol 
• 75343-85-0 (3-Chloro-phenyl)-piperidin-2-yl-methanol 

Relevant articles and documents

Ligand-Free Iridium-Catalyzed Dehydrogenative ortho C?H Borylation of Benzyl-2-Pyridines at Room Temperature

A convenient and ligand-free iridium-catalyzed dehydrogenative ortho C?H borylation of benzyl-2-pyridines has been developed. The reaction proceeds smoothly at room temperature using pinacolborane as a borylating reagent in the presence of catalytic amount of [IrOMe(COD)]2. The reaction is compatible with many functional groups, providing a vast array of ortho borylated products in moderate to excellent yields with excellent selectivities. (Figure presented.).

Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter

Methylphenidate analogues, in which the carbomethoxy has been replaced by an alkyl group and with different phenyl substituents, have been synthesized and tested in monoamine transporter assays. As predicted from a pharmacophore model, most of the RR/SS diastereomers showed high potency as dopamine reuptake inhibitors. Analogues with a 4-chlorophenyl group and an unbranched initial alkyl atom had consistently enhanced selectivity for the dopamine transporter. The most potent compounds were those with a three- or four-carbon chain. The "inactive" RS/SR diastereomers showed substantial activity when the phenyl substituent was 3,4-dichloro. On a locomotor assay, one compound was found to have a slow onset and a long duration of action. The activity of these compounds provides additional evidence for a conformational/superposition model of methylphenidate with cocaine-like structures. A ketone analogue, obtained by hydrogenating a previously described vinylogous amide, had activity similar to that of methylphenidate.