75348-33-3 Usage
General Description
1-(3-chlorophenyl)-2-methylpiperazine is a chemical compound that belongs to the class of piperazine derivatives. It is an organic compound with the molecular formula C11H15ClN2 and a molecular weight of 208.7 g/mol. 1-(3-chlorophenyl)-2-methylpiperazine consists of a piperazine ring with a 3-chlorophenyl group attached at the 1-position and a methyl group at the 2-position. 1-(3-chlorophenyl)-2-methylpiperazine has been researched for its potential pharmacological activities, including its effects on the central nervous system. It has been studied as a potential drug candidate for various therapeutic uses, including as an antipsychotic and anxiolytic agent. 1-(3-chlorophenyl)-2-methylpiperazine is also used as a precursor in the synthesis of other pharmaceutical compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 75348-33-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,3,4 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 75348-33:
(7*7)+(6*5)+(5*3)+(4*4)+(3*8)+(2*3)+(1*3)=143
143 % 10 = 3
So 75348-33-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H15ClN2/c1-9-8-13-5-6-14(9)11-4-2-3-10(12)7-11/h2-4,7,9,13H,5-6,8H2,1H3
75348-33-3Relevant articles and documents
Effect of modifications of the alkylpiperazine moiety of trazodone on 5HT(2A) and α1 receptor binding affinity
Giannangeli, Marilena,Cazzolla, Nicola,Luparini, Maria Rita,Magnani, Maurizio,Mabilia, Massimo,Picconi, Giuseppe,Tomaselli, Mauro,Baiocchi, Leandro
, p. 336 - 345 (2007/10/03)
A series of triazolopyridine derivatives (compounds 2a-1) were synthesized in order to explore the effect of modifications of the alkylpiperazine moiety of trazodone (fragment A) on binding affinity for 5HT(2A) and α1 receptors. All of the synthesized compounds show a decrease of affinity for both 5HT(2A) and α1 receptors, as compared to trazodone, with the exception of compounds 2b,c which bear a methyl group in an α position to the aliphatic nitrogen atom N1. These compounds showed a decrease of affinity only for the α1 receptor. The stereochemical influence of the piperazine moiety of compound 2c was also evaluated. Enantiomer (S)- 2c showed the most significant differences between 5HT(2A) and α1 receptor affinity (IC50 values) and among the corresponding functional properties (pA2 values). Since (S)-2c cannot generate the metabolite 4-(3- chlorophenyl)piperazine this product was selected for further pharmacological studies.
