753502-60-2

Basic information

• Product Name: 1-bromo-2-chloro-4,5-dimethoxy-benzene
• Synonyms: 1-bromo-2-chloro-4,5-dimethoxy-benzene
• CAS NO: 753502-60-2
• Molecular Weight: 251.507
• Mol File: 753502-60-2.mol

Chemical Properties

• Melting Point: 75-77 °C
• Boiling Point: 274.5±35.0 °C(Predicted)
• Density: 1.518±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-bromo-2-chloro-4,5-dimethoxy-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-chloro-4,5-dimethoxy-benzene(753502-60-2)
• EPA Substance Registry System: 1-bromo-2-chloro-4,5-dimethoxy-benzene(753502-60-2)

Safety Data

• Hazardous Substances Data: 753502-60-2(Hazardous Substances Data)

Usage

Appearance

Pale yellow solid
The physical state and color of the compound, indicating its visual characteristics.

Family

Benzene family
The group of organic compounds to which this molecule belongs, characterized by a benzene ring structure.

Substituents

Bromine and chlorine
The halogen atoms (Br and Cl) attached to the benzene ring, which contribute to the compound's reactivity and properties.

Functional groups

Two methoxy groups
The presence of two -OCH3 groups (methoxy) attached to the benzene ring, which influence the compound's polarity and reactivity.

Usage

Building block in organic synthesis
The primary application of the compound, serving as a starting material for the synthesis of more complex organic molecules.

Applications

Pharmaceutical production and other organic compounds
The specific industries in which the compound is utilized, highlighting its importance in creating various products.

Chemical properties

Versatile intermediate compound for synthesis of biologically active molecules
The compound's ability to be used in the creation of a wide range of biologically active molecules, showcasing its utility in chemical research and development.

Hazards

Skin and eye irritation, harmful if swallowed or inhaled
The potential health risks associated with handling the compound, emphasizing the need for proper safety precautions during its use.

Upstream product

• 16766-27-1 4-chloro-1,2-dimethoxybenzene 
• 91-16-7 1,2-dimethoxybenzene 
• 2859-78-1 4-Bromoveratrole 

Downstream Products

• 1541073-30-6 4-(2-chloro-4,5-dimethoxyphenyl)-6-(methoxymethoxy)-7-(4-methoxyphenyl)benzo[d][1,3]dioxol-5-yl formate 
• 1541073-33-9 8,9-dimethoxy-5-(methoxymethoxy)-4-(4-methoxyphenyl)-benzo[b][1,3]dioxolo[4,5-e]benzofuran 
• 1541073-35-1 8,9-dimethoxy-4-(4-methoxyphenyl)benzo[b][1,3]dioxolo-[4,5-e]benzofuran-5-ol 
• 1541073-38-4 benzyl (8,9-dimethoxy-4-(4-methoxyphenyl)benzo[b][1,3]-dioxolo[4,5-e]benzofuran-5-yl)carbonate 
• 1541073-40-8 5-(((benzyloxy)carbonyl )oxy)-8,9-dimethoxy-4-(4-methoxyphenyl)benzo[b][1,3]dioxolo[4,5-e]benzofuran-2-yl acetate 
• 1541073-41-9 benzyl (1,2-dihydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-4-yl)carbonate 
• 1541073-45-3 4-hydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate 
• 1541073-10-2 4,7,8-trimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate 
• 146905-24-0 4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate 
• 1541073-24-8 7-bromo-4-(2-chloro-4,5-dimethoxyphenyl)-6-(methoxymethoxy)benzo[d][1,3]dioxole-5-carbaldehyde 
• 1541073-28-2 4-(2-chloro-4,5-dimethoxyphenyl)-6-(methoxymethoxy)-7-(4-methoxyphenyl)benzo[d][1,3]dioxole-5-carbaldehyde 
• 950662-22-3 (2-chloro-4,5-dimethoxyphenyl)boronic acid 

Relevant articles and documents

Efficient halogenation synthesis method of aryl halide

The invention discloses an efficient halogenation synthesis method of aryl halide. The method comprises the following step: in the presence of a catalyst (sulfoxide or oxynitride), a halogenation reagent and a solvent, carrying out a halogenation reaction on an aromatic ring compound to obtain the aryl halide. According to the present invention, in the presence of a catalyst (sulfoxide or nitrogenoxide), a halogenation reagent and a solvent, the aromatic ring is subjected to an efficient halogenation reaction, such that the very useful aryl halide can be obtained with high activity and high selectivity; and by adopting the method disclosed by the invention, aryl halides can be efficiently synthesized, and the method has a wide application prospect in actual production.

Syntheses of the fungal metabolites Boletopsins 7, 11, and 12 from the Papua New Guinea medicinal mushroom Boletopsis sp.

Boletopsins 7 (1), 11 (2), and 12 (3) are p-terphenyl dibenzofuran compounds, isolated from the Papua New Guinean medicinal mushroom Boletopsis sp. The first syntheses of these fungal metabolites are reported, allowing for an investigation of their antibiotic activity. The key steps include sequential Suzuki-Miyaura couplings to rapidly form the p-terphenyl backbone and an Ullmann ether synthesis on a formate ester to create the dibenzofuran moiety. Biological evaluation of the synthetic compounds and intermediates against a panel of bacterial nosocomial pathogens was performed.

Practical and metal-free electrophilic aromatic halogenation by interhalogen compounds generated in situ from N-halosuccinimide and catalytic TMSCL

Halomonochloride compounds (ClCl, BrCl, ICl) generated in situ from N-halosuccinimide and catalytic chlorotrimethylsilane (TMSCl, 0.1 equiv) can efficiently halogenate aromatic compounds to give halogenated products in good to excellent yields and selectivities. The reaction can be carried out at room temperature or at lower temperatures, requires only one hour, is practical to apply to a wide range of substrates, and provides a simple access to a variety of haloarene compounds. Georg Thieme Verlag Stuttgart New York.

Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones

(Chemical Equation Presented) Polychlorinated biphenyls (PCBs) comprise a group of persistent organic pollutants that differ significantly in their physicochemical properties, their persistence, and their biological activities. They can be metabolized via

Efficient halogenation of aromatic systems using N-halosuccinimides in ionic liquids

A simple, rapid and highly regioselective green protocol has been developed for the halogenation of aromatic systems with N-halosuccinimides using room temperature ionic liquids (ILs) as novel and recyclable reaction media to produce the corresponding halogenated aromatic compounds in high to quantitative yields. N-Halosuccinimides show enhanced reactivity in ionic liquids thereby reducing the reaction times dramatically and improving the yields substantially.