950662-22-3

Usage

Uses

Used in Organic Synthesis:
(2-chloro-4,5-dimethoxyphenyl)boronic acid is used as a reagent in organic synthesis, particularly in the field of medicinal chemistry and drug development. Its unique chemical structure allows it to be a valuable building block for the synthesis of biologically active molecules.
Used in Suzuki-Miyaura Cross-Coupling Reactions:
In the field of medicinal chemistry, (2-chloro-4,5-dimethoxyphenyl)boronic acid is used as a reactant in Suzuki-Miyaura cross-coupling reactions to form carbon-carbon bonds. This reaction is crucial for the synthesis of complex organic molecules, including pharmaceutical compounds.
Used in Materials Science:
(2-chloro-4,5-dimethoxyphenyl)boronic acid has been researched for its potential applications in materials science. Its unique properties make it a promising candidate for the development of new materials with specific characteristics.
Used in Catalysis:
Additionally, (2-chloro-4,5-dimethoxyphenyl)boronic acid has been explored for its potential use in catalysis. Its unique chemical structure allows it to act as a catalyst in various chemical reactions, contributing to the efficiency and selectivity of these processes.

Upstream product

• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 121-43-7 Trimethyl borate 
• 753502-60-2 1-bromo-2-chloro-4,5-dimethoxy-benzene 
• 16766-27-1 4-chloro-1,2-dimethoxybenzene 

Downstream Products

• 1541073-30-6 4-(2-chloro-4,5-dimethoxyphenyl)-6-(methoxymethoxy)-7-(4-methoxyphenyl)benzo[d][1,3]dioxol-5-yl formate 
• 1541073-33-9 8,9-dimethoxy-5-(methoxymethoxy)-4-(4-methoxyphenyl)-benzo[b][1,3]dioxolo[4,5-e]benzofuran 
• 1541073-35-1 8,9-dimethoxy-4-(4-methoxyphenyl)benzo[b][1,3]dioxolo-[4,5-e]benzofuran-5-ol 
• 1541073-38-4 benzyl (8,9-dimethoxy-4-(4-methoxyphenyl)benzo[b][1,3]-dioxolo[4,5-e]benzofuran-5-yl)carbonate 
• 1541073-40-8 5-(((benzyloxy)carbonyl )oxy)-8,9-dimethoxy-4-(4-methoxyphenyl)benzo[b][1,3]dioxolo[4,5-e]benzofuran-2-yl acetate 
• 1541073-41-9 benzyl (1,2-dihydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-4-yl)carbonate 
• 1541073-45-3 4-hydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate 
• 1541073-10-2 4,7,8-trimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate 
• 146905-24-0 4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate 
• 1541073-28-2 4-(2-chloro-4,5-dimethoxyphenyl)-6-(methoxymethoxy)-7-(4-methoxyphenyl)benzo[d][1,3]dioxole-5-carbaldehyde 
• 1541073-24-8 7-bromo-4-(2-chloro-4,5-dimethoxyphenyl)-6-(methoxymethoxy)benzo[d][1,3]dioxole-5-carbaldehyde 

Relevant academic research and scientific papers

Syntheses of the fungal metabolites Boletopsins 7, 11, and 12 from the Papua New Guinea medicinal mushroom Boletopsis sp.

Boletopsins 7 (1), 11 (2), and 12 (3) are p-terphenyl dibenzofuran compounds, isolated from the Papua New Guinean medicinal mushroom Boletopsis sp. The first syntheses of these fungal metabolites are reported, allowing for an investigation of their antibiotic activity. The key steps include sequential Suzuki-Miyaura couplings to rapidly form the p-terphenyl backbone and an Ullmann ether synthesis on a formate ester to create the dibenzofuran moiety. Biological evaluation of the synthetic compounds and intermediates against a panel of bacterial nosocomial pathogens was performed.

PYRROLOPYRIMIDINE DERIVATIVES USED AS HSP90 INHIBITORS

Compounds of formula (I) have HSP90 inhibitory activity and are therefore useful in the treatment of, inter alia, cancer: Formula (I) wherein Ri is hydrogen, fluoro, chloro, bromo, or a radical of formula -X-Alk1-(Z)m-(Alk2)n-Q wherein X is -O-, -S- -S(O)-, -SO2-, or -NH-, Z is -O-, -S-, -(C=O)-, -(C=S)-, -S(O)-, -SO2-, -NRA-, or, in either orientation -C(=O)O-, -C(=O)NRA- , -C(=S)NRA-, -SO2NRA-, -NRAC(=O)-, or -NRASO2- wherein RA is hydrogen or C1-C6 alkyl AIk1 and AIk2 are optionally substituted divalent C1-C3 alkylene or C2-C3 alkenylene radicals, m, n and p are independently 0 or 1 , and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical; R2 is a radical of formula -(Ar1)p-(Alk1)q-(Z)r-(Alk2)s-Q wherein Ar1 is an optionally substituted aryl or heteroaryl radical, Alk1, Alk2, Z, and Q are as defined above, and p, q, r and s are independently 0 or 1 ; and R3 is cyano (-CN), fluoro, chloro, bromo, methyl in which in which one or more hydrogen atoms are optionally replaced by fluorine atoms, ethyl in which in which one or more hydrogen atoms are optionally replaced by fluorine atoms, cyclopropyl, -OH, -CH2OH, -C(O)NH2, -C(O)CH3, Or -NH2.