75391-97-8

Basic information

• Product Name: 4-Methyl-N-(2-pyridinylmethyl)-benzenesulfonamide
• Synonyms: N-(2-Pyridylmethyl)-4-toluenesulfonamide;N-(Pyridyl-2-methyl)-p-toluenesulfonamide
• CAS NO: 75391-97-8
• Molecular Formula: C₁₃H₁₄N₂O₂S
• Molecular Weight: 262.33
• Mol File: 75391-97-8.mol
• Article Data: 17

Chemical Properties

• Melting Point: 76-77 °C
• Boiling Point: 429.5°C at 760 mmHg
• Flash Point: 213.6°C
• Appearance: /
• Density: 1.247g/cm³
• Vapor Pressure: 1.39E-07mmHg at 25°C
• Refractive Index: 1.59
• PKA: 9.78±0.50(Predicted)
• CAS DataBase Reference: 4-Methyl-N-(2-pyridinylmethyl)-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-N-(2-pyridinylmethyl)-benzenesulfonamide(75391-97-8)
• EPA Substance Registry System: 4-Methyl-N-(2-pyridinylmethyl)-benzenesulfonamide(75391-97-8)

Safety Data

• Hazardous Substances Data: 75391-97-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H14N2O2S/c1-11-5-7-13(8-6-11)18(16,17)15-10-12-4-2-3-9-14-12/h2-9,15H,10H2,1H3

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 98-59-9 p-toluenesulfonyl chloride 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 586-98-1 2-Hydroxymethylpyridine 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 117053-67-5 N,N-di(2-picolyl)-4-methylbenzenesulfonamide 
• 90719-72-5 N,N'-Ditosyl-6,6'-bis<(2-pyridylmethyl)aminomethyl>-2,2'-bipyridin 
• 90719-78-1 2,6-bis{[(pyrid-2-ylmethyl)(tosyl)amino]methyl}pyridine 
• 502723-66-2 [6-{[(pyrid-2-ylmethyl)(tosyl)amino]methyl}pyrid-2-yl]methanol 
• 873948-86-8 4-amino-3,5-bis{[N-(2-pyridylmethyl)-N-(4-toluenesulfonyl)amino]methyl}-4H-1,2,4-triazole 
• 1539-42-0 bis[(2-pyridyl)methyl]amine 
• 77405-26-6 Ni(C₅H₄NCH₂NSO₂C₆H₄CH₃)2(H₂O)2 
• 353248-11-0 [copper(II)(N-(2-methylpyridyl)toluenesulfonylamidate)2] 
• 475598-57-3 [Co(II)(4-methyl-N-(2-pyridylmethyl)benzenesulfonamide)2(2,2'-bipyridine)] 
• 475598-58-4 [Co(II)(4-methyl-N-(2-pyridylmethyl)benzenesulfonamide)2(1,10-phenanthroline)] 
• 84119-90-4 Co((tosyl)-N-(pyridin-2-ylmethyl)-sulfonamide)₂ 
• 507486-42-2 [Ni(CH₃C₆H₄SO₂NCH₂C₅H₄N)2] 
• 507483-52-5 [Zn(CH₃C₆H₄SO₂NCH₂C₅H₄N)2] 
• 1054582-75-0 [(NC₅H₄CH₂NSO₂C₆H₄CH₃)AuCl₂] 

Relevant articles and documents

Preparation method of sulfonyl amidine with 2-Picolylamine and DMF-DMA as amine sources

The invention discloses a preparation method of sulfonyl amidine with 2-Picolylamine and DMF-DMA as amine sources. The method comprises the following steps: reacting sulfonyl chloride with 2-Picolylamine to obtain an intermediate product; and then reacting the intermediate product with DMF-DMA in the presence of a catalyst at a temperature of 60-100 DEG C, then performing cooling to room temperature, extracting the reaction solution with ethyl acetate, performing layering, drying and then concentrating to obtain a target product sulfonyl amidine. According to the method disclosed by the invention, the reaction of secondary sulfonamide and DMF-DMA is realized, and the synthesis path of sulfonyl amidine is expanded. The synthetic reaction is simple in operation, mild in condition and convenient in post-treatment, and the obtained intermediate product and the product are high in purity and yield.

Synthesis, Characterization, and Reactivity of an Ethynyl Benziodoxolone (EBX)-Acetonitrile Complex

The synthesis of a crystalline ethynyl-1,2-benziodoxol-3(1H)-one (EBX)-acetonitrile complex is described. EBX has been widely used as an active species for a variety of reactions; however, its high instability has so far prevented its isolation. The EBX-acetonitrile is self-assembled into a double-layered honeycomb structure through weak hypervalent iodine secondary interactions and hydrogen bonding. The N-ethynylation of a variety of sulfonamides using the EBX-acetonitrile complex as a substrate under mild conditions is also described.

One-Pot Synthesis of Sulfonamides from Sodium Sulfinates and Amines via Sulfonyl Bromides

a new and convenient procedure has been developed for the preparation of sulfonamides from sodium sulfinates and amines with (n-C4H9)4NBr as bromine source and m-chloroperbenzoic acid as oxidant. This S-N bond formation reaction proceeds efficiently via sulfonyl bromides under neutral conditions to afford the corresponding sulfonamides in good yields at room temperature.