754-19-8Relevant academic research and scientific papers
Deuterium-exchange reaction in a CF3CHBrCl-D2O two-liquid phase system
Ogata, Yukio,Sugihara, Kei-ichi,Sakka, Tetsuo,Iwasaki, Matae
, p. 285 - 292 (1992)
An alkali-catalyzed hydrogen isotope exchange reaction was studied in a CF3CHBrCl-D2O two liquid phase system.The exchange rate was comparable to that in the CHCl3-D2O system previously recognized as the system having the highest exchange rate under alkaline conditions.It was confirmed that CF3CHBrCl was resistant to decomposition caused by alkali.These properties indicate that CF3CHBrCl could be a candidate for a working material in laser hydrogen-isotope separation processes.
Synthesis of Chiral α-CF3-Substituted Benzhydryls via Cross-Coupling Reaction of Aryltitanates
Varenikov, Andrii,Shapiro, Evgeny,Gandelman, Mark
supporting information, p. 9386 - 9391 (2020/12/21)
We describe a highly efficient approach toward α-CF3-substituted benzhydryls thanks to the employment of organotitanium(IV) based nucleophiles. The use of commercially available anesthetic halothane as a cheap fluorinated building block in a sequential one-pot nickel-catalyzed enantioselective cross-coupling reaction of aryl titanates allowed for the synthesis of chiral α-CF3-substituted benzhydryls in good yields and excellent enantioselectivities. Alternatively, α-CF3-benzyl bromides could be employed under similar conditions to obtain the same family of compounds in higher yields and excellent selectivities. A benzhydryl moiety is a common motif in many biologically active compounds, and their enantioenriched fluorinated analogs should be of great interest in the search for novel drugs and agrochemicals.
Enthalpy of Mixing of Liquid Binary Mixtures with Component Association. The System Dioxolane-Halothane
Francesconi, R.,Lunelli, B.,Comelli, F.
, p. 109 - 118 (2007/10/02)
The mixture halothane-dioxolane was investigated by means of FT-IR to get the pattern of the association reactions.By entering such information together with earlier calorimetric data into the formulae for a model of associated liquid solutions proposed previously, we could evaluate the equilibrium constants and the enthalpy changes of the association reactions, as well as some parameters characteristic of the extended regular solution model.A comparison is made between the results obtained from different implementations of the overall procedure.Solutions / Equilibria / Associations / Dioxolane / Halothane
Compositions and methods for anesthetizing an animal using deuterated analogues of halothane and chloroform
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, (2008/06/13)
Deuterated analogues of halothane and chloroform are used to anesthetize an animal.
