75400-57-6Relevant articles and documents
METHODS FOR FORMING SATURATED (HETERO)CYCLIC BORYLATED HYDROCARBONS AND RELATED COMPOUNDS
-
Paragraph 0058, (2018/03/25)
The disclosure relates to methods for forming at least partially saturated cyclic and heterocyclic borylated hydrocarbons, as well as related compounds, which can be precursor compounds in the synthesis of any of a variety of pharmaceutical or medicinal compounds with a desired structure and/or stereochemistry for drug synthesis or drug candidate evaluation. The methods generally include reduction of an unsaturated cyclic or heterocyclic borylated hydrocarbon having a boron-containing substituent at an sp2-carbon, where such reduction converts the sp2-carbon to an sp3-carbon at the point of attachment of the boron-containing substituent. The methods can exhibit a selectivity for syn-addition during reduction, which can provide stereospecific products, such as when the unsaturated cyclic or heterocyclic reactant is multiply substituted with boron groups and/or other functional groups.
Rearrangement of 2,5-bis(silylated)-N-boc pyrroles into the corresponding 2,4-species
Mirebeau, Jean-Hugues,Haddad, Mansour,Henry-Ellinger, Martin,Jaouen, Gerard,Louvel, Julien,Le Bideau, Franck
supporting information; experimental part, p. 8890 - 8892 (2010/03/01)
(Chemical Equation Presented) The rearrangement of 2,5-bis(silylated)-N-Boc pyrroles in their 2,4-isomers is shown to proceed under mild acidic conditions. A reasonable mechanism, based on literature as well as experiments, is proposed to rationalize this
2-Substituted pyrroles from N-tert-butoxycarbonyl-2-bromopyrrole: N-tert-butoxycarbonyl-2-trimethylsilylpyrrole
Chen, Wha,Stephenson, E. Kyle,Cava, Michael P.,Jackson, Yvette A.
, p. 151 - 151 (2017/05/20)
-
