75413-12-6Relevant academic research and scientific papers
Synthesis of fluorescent trisubstituted oxazoles via a facile tandem Staudinger/aza-Wittig/isomerization reaction
Xie, Hai,Rao, Yong,Ding, Ming-Wu
, p. 440 - 447 (2017)
A new facile synthesis of trisubstituted oxazoles starting from azides was developed. The reactions of azides with triphenyl phosphine afforded the corresponding 2,4,5-trisubstituted oxazole derivatives via tandem Staudinger, aza-Wittig and isomerization reaction either thermally or under basic conditions. Properties of the oxazole derivatives were surveyed and some of the examples showed reasonable fluorescence. The greatest fluorescence intensity was observed when the 2- and the 5- substituents on the oxazole ring were aromatic groups (with ε?=?2.3–3.0?×?104?mol?1?dm3?cm?1 and Φ?=?0.25–0.29 relative to quinine sulphate). However, the fluorescence intensity was diminished when either the 2- or the 5-substituent was H or alkyl.
A NEW SYNTHESIS OF OXAZOLES
Bhatt, M. Vivekananda,Reddy, Gaddam Subba
, p. 2359 - 2360 (2007/10/02)
Oxazoles are prepared from the ketoximes in a single pot sequence.
