754171-58-9Relevant academic research and scientific papers
High-affinity, non-peptide agonists for the ORL1 (Orphanin FQ/nociceptin) receptor
R?ver, Stephan,Adam, Geo,Cesura, Andrea M.,Galley, Guido,Jenck, Fran?ois,Monsma Jr., Frederick J.,Wichmann, Jürgen,Dautzenberg, Frank M.
, p. 1329 - 1338 (2007/10/03)
The discovery of 8-(5,8-dichloro-1,2,3,4-tetrahydro-napthalene-2-yl)-1- phenyl-1,3,8-triazaspiro[4.5]decan-4-one, 1a, as a high-affinity ligand for the human ORL1 (orphanin FQ/nociceptin) receptor led to the synthesis of a series of optimized ligands. The
