754188-57-3Relevant academic research and scientific papers
Chirality induction and chiron approaches to enantioselective total synthesis of α-lipoic acid
Chavan, Subhash P.,Pawar, Kailash P.,Praveen, Ch.,Patil, Niteen B.
, p. 4213 - 4218 (2015)
Abstract An efficient, short and convenient asymmetric synthesis of (R)-(+)-lipoic acid in seven steps from chiral hydroxy aldehyde with 32.5% overall yield is described. Synthesis of S and R enantiomers of α-lipoic acid from cis-1,4-butene diol derived chiral lactone is reported with 34 % overall yield. The present synthesis involves use of simple reaction conditions making it a convenient synthesis.
Enantioselective synthesis of R-(+)-α and S-(-)-α-lipoic acid
Chavan, Subhash P.,Praveen, Cherukupally,Ramakrishna,Kalkote
, p. 6027 - 6028 (2007/10/03)
An efficient synthesis of α-lipoic acid from the readily available cis-2-butene-1,4-diol employing a Claisen orthoester rearrangement and Sharpless asymmetric dihydroxylation as the key steps, is described.
