7543-20-6

Usage

Uses

Used in Pharmaceutical Research:
Ethanone, 1-phenyl-2-(4-quinolinyl)is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
Ethanone, 1-phenyl-2-(4-quinolinyl)serves as a versatile building block in organic synthesis, enabling the creation of a wide range of chemical products with diverse applications.
Used in Anti-inflammatory Applications:
Ethanone, 1-phenyl-2-(4-quinolinyl)is used as an anti-inflammatory agent due to its potential to modulate inflammatory pathways and reduce inflammation in various conditions.
Used in Anticancer Applications:
Ethanone, 1-phenyl-2-(4-quinolinyl)is employed as an anticancer agent, exhibiting potential inhibitory effects on the growth and progression of cancer cells. Its ability to target multiple signaling pathways makes it a promising candidate for cancer therapy.
Used in Antimicrobial Applications:
Ethanone, 1-phenyl-2-(4-quinolinyl)is used as an antimicrobial agent, demonstrating potential activity against various microorganisms, including bacteria and fungi. Its ability to disrupt microbial growth and survival makes it a valuable tool in the development of new antimicrobial drugs.
Used in Drug Development:
Ethanone, 1-phenyl-2-(4-quinolinyl)is utilized in the development of new drugs and pharmaceutical applications, leveraging its potential biological activities and unique chemical properties to create innovative therapeutic agents.

Upstream product

• 138-89-6 p-dimethylaminonitrosobenzene 
• 98-86-2 acetophenone 
• 93-58-3 benzoic acid methyl ester 
• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 93-89-0 benzoic acid ethyl ester 
• 113999-77-2 2-[1-(4-chloro-benzyl)-1H-[4]chinolyLiDene]-1-phenyl-ethanone 
• 112440-93-4 2-[1-(2,4-dichloro-benzyl)-1H-[4]chinolyLiDene]-1-phenyl-ethanone 
• 70437-06-8 1-phenyl-2-(4-quinolyl)acetylene 

Relevant academic research and scientific papers

Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

Pyrazole-based inhibitors of the transforming growth factor-β type I receptor kinase domain (TβR-I) are described. Examination of the SAR in both enzyme- and cell-based in vitro assays resulted in the emergence of two subseries featuring differing selectivity versus p38 MAP kinase. A common binding mode at the active site has been established by successful cocrystallization and X-ray analysis of potent inhibitors with the TβR-I receptor kinase domain.

The Mechanism of Imine-Enamine Tautomerism of 2- and 4-Phenacylquinolines

Isomerisations of 2- and 4-phenacylquinolines to their enaminone tautomers via 1,3 or 1,5 carbon-nitrogen hydrogen shifts occur by stepwise acid- or base-catalysed pathways simolar to those for the enolisation of ketones.The reactions are observed as relaxations of the unstable to stable tautomers by stopped-flow spectrophotometry or, where the aromatic imine is the stable form, by trapping the enaminone with iodine in the reverse reaction.Evidence of mechanism comes from observations of general acid and general base catalysis, agreement between kinetically determined pKa values and independently measured values, and comparisons between rate and equilibrium constants for protonation of the enaminone tautomers and their N-methyl derivatives.The reactions show a primary isotope effect and yield normal Broensted plots with α ca. 0.5.The kinetically determined pKa values indicate N- rather than O-protonation of phenacylquinolines but for the enaminones O-protonation competes kinetically with the thermodynamically preferred C-protonation.Combination of pKa values for C-, N-, and O-protonation leads to equilibrium constants Kτ for enamine-imine and (protonated) keto-enol tautomerisation.The effect of 2- and 4-N-protonation (proton activating factors) upon rates and equilibria for ionisation of hydrogen from the methylene carbons is discussed and evidence of 'imbalance' in charge development on the carbon base in the transition state is noted.A concerted intramolecular 1,3-proton transfer is predicted but not observed.