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Usage

Uses

Used in Chemical Research:
4-Fluoro-N-Piperidin-4-yl-Benzamide is used as a research compound for exploring its specific properties, potential toxicity, and practical applications in various chemical processes.
Used in Pharmaceutical Development:
4-Fluoro-N-Piperidin-4-yl-Benzamide is used as a lead compound in the development of new pharmaceuticals, given its unique structure and potential for interaction with biological targets.
Used in Material Science:
4-Fluoro-N-Piperidin-4-yl-Benzamide is used as a component in the synthesis of new materials with specific properties, such as improved stability or reactivity, for applications in various industries.
Used in Analytical Chemistry:
4-Fluoro-N-Piperidin-4-yl-Benzamide is used as an analytical standard or reference compound in the development and validation of analytical methods, such as chromatography or spectroscopy, for the identification and quantification of related compounds in complex mixtures.

Upstream product

• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 456-22-4 4-Fluorobenzoic acid 
• 913634-42-1 tert-butyl 4-(4-fluorobenzamido)piperidine-1-carboxylate 
• 132442-35-4 N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide 

Downstream Products

• 287200-24-2 4-{4-[4-(4-fluorobenzamido)piperidino]but-2-ynoxyl}-2-isopropylidenecoumaran-3-one 
• 287200-29-7 4-{4-[4-(4-fluorobenzamido)piperidinomethyl]phenylmethoxyl}-2-isopropylidenecoumaran-3-one 
• 287200-32-2 4-{3-[4-(4-fluorobenzamido)piperidinomethyl]phenylmethoxy}-2-isopropylidenecoumaran-3-one 
• 287200-36-6 4-{2-[4-(4-fluorobenzamido)piperidinomethyl]phenylmethoxy}-2-isopropylidenecoumaran-3-one 
• 283167-17-9 N-(1-benzoylpiperidin-4-yl)-4-fluorobenzamide 
• 283167-11-3 4-(4-fluorobenzoylamino)-1-methoxycarbonylpiperidine 
• 283167-13-5 4-(4-fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine 
• 1094173-11-1 C₃₂H₃₇FN₄O₂ 
• 283167-14-6 4-(4-fluorobenzoylamino)-1-methylsulfonylpiperidine 

Relevant academic research and scientific papers

Synthesis and structure–activity relationship of N-(piperidin-4-yl)benzamide derivatives as activators of hypoxia-inducible factor 1 pathways

Guided by bioisosterism and pharmacokinetic parameters, we designed and synthesized a series of novel benzamide derivatives. Preliminary in vitro studies indicated that compounds 10b and 10j show significant inhibitory bioactivity in HepG2 cells (IC50 values of 0.12 and 0.13?μM, respectively). Compounds 10b and 10j induced the expression of HIF-1α protein and downstream target gene p21, and upregulated the expression of cleaved caspase-3 to promote tumor cells apoptosis.

2-alkylidene hydroxycumaranone derivatives

Compounds of the formula wherein R,R′, A,B,T and x have the meaning given in the specification possess uPA (urokinase-type plasminogen activator) antagonist activity and can be employed as antitumor and/or antimetastatic agents.