75488-69-6

Basic information

• Product Name: N-(9-ethoxy-1,2,3-trimethoxy-10-oxo-5,6,7,10-tetrahydrobenzo[a]heptalen-7-yl)acetamide
• CAS NO: 75488-69-6
• Molecular Formula: C₂₃H₂₇NO₆
• Molecular Weight: 413.4636
• Mol File: 75488-69-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 728.3°C at 760 mmHg
• Flash Point: 394.3°C
• Density: 1.23g/cm³
• Vapor Pressure: 4.54E-21mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: N-(9-ethoxy-1,2,3-trimethoxy-10-oxo-5,6,7,10-tetrahydrobenzo[a]heptalen-7-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(9-ethoxy-1,2,3-trimethoxy-10-oxo-5,6,7,10-tetrahydrobenzo[a]heptalen-7-yl)acetamide(75488-69-6)
• EPA Substance Registry System: N-(9-ethoxy-1,2,3-trimethoxy-10-oxo-5,6,7,10-tetrahydrobenzo[a]heptalen-7-yl)acetamide(75488-69-6)

Safety Data

• Hazardous Substances Data: 75488-69-6(Hazardous Substances Data)

Upstream product

• 1117-96-0 Diazoethan 
• 477-27-0 colchiceine 
• 64-67-5 diethyl sulfate 
• 64-17-5 ethanol 
• 518-12-7 (7S)-isocolchicine 
• 104-15-4 toluene-4-sulfonic acid 
• 64-86-8 colchicine 
• 3087-36-3 titanium (IV) ethoxide 
• 129491-66-3 9-demethyl-9-tosylisocolchicine 
• 75-03-6 ethyl iodide 
• 6192-52-5 p-toluenesulfonic acid monohydrate 

Relevant articles and documents

Synthesis of 1,3-diazaazulene derivatives of colchicinoids and isocolchicinoids via ipso- or tele-substitution-condensation with amidines

Condensation of colchicinoids and isocolchicinoids with amidines in dry benzene affords regioselectively 1,3-diazaazulene derivatives: ipso- substitution-condensation products (e.g. 7) are best obtained from cycloheptatrienone-ring deactivated substrates (e.g. 4), whereas isomeric tele-substitution-condensation products (e.g. 13), are best accessible from cycloheptatrienone-ring activated substrates (e.g. 10). Hydroxylic solvents inhibit tele-substitution-condensation, arguably by undergoing protonation in preference of the intermediate σ adduct.

Comparison of inhibitory effects of colchicine, isocolchicine and homologous compounds on cell division.

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