75490-55-0

Usage

Uses

Used in Pharmaceutical Industry:
2,2-dimethyl-4-oxo-4-phenylbutanenitrile serves as a key building block in the synthesis of various pharmaceuticals and chemical compounds. Its unique structure and properties make it a valuable intermediate for the development of new drugs and medicinal agents.
Used in Chemical Compound Synthesis:
In the chemical industry, 2,2-dimethyl-4-oxo-4-phenylbutanenitrile is utilized as an intermediate for the production of a wide range of chemical compounds. Its versatility in chemical reactions allows for the creation of diverse products with various applications across different sectors.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 5650-07-7 3-methyl-1-phenyl-but-2-en-1-one 
• 124286-37-9 3-methyl-3-nitro-1-phenylbutan-1-one 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 78-67-1 2,2'-azobis(isobutyronitrile) 
• 100-42-5 styrene 

Relevant academic research and scientific papers

Copper-Catalyzed Oxidative Coupling of AIBN and Ketone-Derived Enoxysilanes to γ-Ketonitriles

A new and efficient oxidative coupling reaction between enoxysilane and alkylnitrile radicals derived from readily available AIBN and its analogues has been developed by using redox-active metal as a catalyst in which the redox-active copper is used for enhancing the electrophilicity of a free radical via coordination and bringing the radical and nucleophilic enol ether closer to facilitate the single-electron transfer. The present catalytic protocol afforded a variety of γ-ketonitriles in good to excellent yields with good functional group tolerance.

Synthesis of β-nitro ketones from geminal bromonitroalkanes and silyl enol ethers by visible light photoredox catalysis

Various β-nitro ketones, including those bearing a β-tertiary carbon, were prepared from geminal bromonitroalkanes and trimethylsilyl enol ethers of a broad range of ketones by visible light photoredox catalysis, which were then easily converted into β-amino ketones, 1,3-amino alcohols, α,β-unsaturated ketones, β-cyano ketones and γ-nitro ketones.

Unactivated C(sp3)-H Bond Functionalization of Alkyl Nitriles with Vinylarenes and Mechanistic Studies

The first example of a metal-free unactivated C(sp3)-H bond functionalization of alkyl nitriles with terminal vinylarenes to provide γ-ketonitrile derivatives is described. This protocol features simple operations, a broad substrate scope, and atom and step economy. In addition, Cu-catalyzed C(sp3)-H bond functionalization of azodiisobutyronitrile (AIBN) and analogues with terminal vinylarenes to generate γ-ketonitriles was also studied. A preliminary free-radical pathway was confirmed by capturing an alkyl radical, and a conjugate system was found that can stabilize radical intermediates and be in favor of this transformation. Density functional theory (DFT) calculations also provide important evidence of the free-radical pathway.