75499-78-4

Upstream product

• 38444-50-7 2,4,5-trimethoxybenzeneacetonitrile 
• 30038-31-4 (2,4,5-trimethoxyphenyl)methanol 
• 53811-44-2 2,4,5-trimethoxybenzyl chloride 
• 4460-86-0 asaraldehyde 
• 4463-16-5 2,4,5-trimethoxyphenylacetic acid 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 2638-15-5 methyl 2-(2,4,5-trimethoxyphenyl)acetate 

Downstream Products

• 111596-43-1 6,7-Dimethoxy-1-(2,4,5-trimethoxy-benzyl)-3,4-dihydro-1H-isoquinoline-2-carbaldehyde 
• 111619-16-0 1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(2,4,5-trimethoxybenzyl)isoquinoline 
• 111596-44-2 3-(4,5-dimethoxy-2-vinylphenyl)-5,7-dimrthoxy-2-methyl-isoquinolin-1(2H)-one 
• 111596-41-9 3-(4,5-dimethoxy-2-vinylphenyl)-5,7,8-trimethoxy-2-methyl-isoquinolin-1(2H)-one 
• 75499-79-5 3,4-dihydro-6,7-dimethoxy-1-(2,4,5-trimethoxybenzyl)isoquinoline hydrochloride 
• 111596-38-4 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2,4,5-trimethoxybenzyl)isoquinoline 

Relevant academic research and scientific papers

Chemical Transformation of Protoberberines. Part 10. A Novel Synthesis of Sanguilutine and Dihydrosanguilutine, fully Aromatised 2,3,7,8,10-Pentaoxygenated Benzophenanthridine Alkaloids

2,3,7,8,10-Pentaoxygenated benzophenanthridine alkaloids, sanguilutine (1) and dihydrosanguilutine (2), were efficiently synthesized from the corresponding 2,3,9,10,12-pentamethoxyprotoberberine (8) through a regioselective C(6)-N bond cleavage, followed by recombination between the original C(6) and C(13) positions of compound (8) according to a biomimetic route.

Studies on Tetrahydroisoquinolines. Part 15. Lead Tetra-acetate Oxidation of Four Hydroxytetrahydroprotoberberines, (+/-)-Govanine, (+/-)-Discretine, (+/-)-Corytencine, and (+/-)-10-Hydroxy-2,3,11-trimethoxytetrahydroprotoberberine

Lead tetra-acetate oxidation of (+/-)-2- (1) and (+/-)-10- (2) hydroxytetrahydroprotoberberines afforded the p-quinol acetates (5) and (6), which on treatment with acetic anhydride-concentrated sulphuric acid gave (+/-)-2,5β- (35), and (+/-)-10,13α- (40)