38444-50-7

Upstream product

• 53811-44-2 2,4,5-trimethoxybenzyl chloride 
• 143-33-9 sodium cyanide 
• 50-00-0 formaldehyd 
• 4460-86-0 asaraldehyde 
• 151-50-8 potassium cyanide 
• 490-64-2 asaronic acid 
• 20029-76-9 methyl 2,4,5-trimethoxybenzoate 
• 30038-31-4 (2,4,5-trimethoxyphenyl)methanol 
• 38449-36-4 (2,4,5-trimethoxy-phenyl)-pyruvic acid 

Downstream Products

• 72545-40-5 2',4',6'-trihydroxy-(2,4,5-trimethoxyphenyl)acetophenone 
• 4463-16-5 2,4,5-trimethoxyphenylacetic acid 
• 854866-54-9 4-dimethylamino-2-(2,4,5-trimethoxy-phenyl)-butyronitrile 
• 6468-53-7 2-hydroxy-2',4,4',5',6-pentamethoxybenzoin 
• 93904-24-6 <2.4.6-Trihydroxy-3-methoxy-phenyl>-<2.4.5-trimethoxy-benzyl>-keton 
• 15394-83-9 1-(2,4,5-trimethoxyphenyl)-2-aminoethane 
• 60059-04-3 2-Methyl-2-(2,4,5-trimethoxy-phenyl)-propionitrile 
• 2638-15-5 methyl 2-(2,4,5-trimethoxyphenyl)acetate 
• 478165-17-2 (4-methoxy-3,6-dioxo-cyclohexa-1,4-dienyl)-acetic acid methyl ester 
• 72545-41-6 2',4',5,5',7-pentamethoxyisoflavone 
• 111596-41-9 3-(4,5-dimethoxy-2-vinylphenyl)-5,7,8-trimethoxy-2-methyl-isoquinolin-1(2H)-one 
• 111596-44-2 3-(4,5-dimethoxy-2-vinylphenyl)-5,7-dimrthoxy-2-methyl-isoquinolin-1(2H)-one 
• 111596-38-4 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(2,4,5-trimethoxybenzyl)isoquinoline 
• 111619-16-0 1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(2,4,5-trimethoxybenzyl)isoquinoline 

Relevant academic research and scientific papers

Studies on the total synthesis of Hirtellanine A: Regioselective synthesis of benzopyran

The total synthesis of Hirtellanine A was accomplished by two different synthetic approaches. Hirtellanine A was assembled using a one-pot, tandem acid-mediated deprotection and tautomerization cascade starting from quinone derivative 23. The key features

Design, synthesis, and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hydroxyphenylpyruvate dioxygenase

An epoxybenzoquinone, 4-hydroxyphenoxypropionic acid, and 2-hydroxy-3-phenyl-3-butenoic acid derivatives have been designed, synthesized, and evaluated for in vitro inhibition activity against 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) from pig liver by the spectrophotometric enol-borate method. The biological data demonstrated that neither epoxybenzoquinone ester nor 2-hydroxy-3-phenyl-3-butenoic acid is an inhibitor of 4-HPPD. The most potent 4-HPPD inhibitor tested was 3-hydroxy-4-phenyl-2(5H)-furanone with an IC50 value of 0.5 μM, which may serve as a lead compound for further design of more potent 4-HPPD inhibitors.

Chemical Transformation of Protoberberines. Part 10. A Novel Synthesis of Sanguilutine and Dihydrosanguilutine, fully Aromatised 2,3,7,8,10-Pentaoxygenated Benzophenanthridine Alkaloids

2,3,7,8,10-Pentaoxygenated benzophenanthridine alkaloids, sanguilutine (1) and dihydrosanguilutine (2), were efficiently synthesized from the corresponding 2,3,9,10,12-pentamethoxyprotoberberine (8) through a regioselective C(6)-N bond cleavage, followed by recombination between the original C(6) and C(13) positions of compound (8) according to a biomimetic route.