755008-34-5Relevant academic research and scientific papers
The first enantioselective halo aldol reaction of ethyl propiolate and aldehydes
Chen, Dianjun,Timmons, Cody,Liu, Junying,Headley, Allan,Li, Guigen
, p. 3330 - 3335 (2004)
The first enantioselective halo aldol reaction of ethyl propiolate with aldehydes has been established by using Jacobsen's chiral cyclohexylsalen ligand. The reaction was conducted at -20 °C in dichloromethane with Et 2AlI as the source of halo
The first asymmetric catalytic halo aldol reaction of β-iodo allenoates with aldehydes by using chiral salen catalyst
Chen, Dianjun,Guo, Li,Kotti, S. R. S. Saibabu,Li, Guigen
, p. 1757 - 1762 (2007/10/03)
The first asymmetric catalytic halo aldol reaction of β-iodo allenoates with aldehydes was established. The reaction was successfully achieved by using (R,R)-SalenAlCl as the chiral catalyst and LiI as an additive at 0°C in dichloromethane. Moderate to good yields and up to 62% ee were obtained. The new system showed a good substrate scope in which both aromatic aldehydes and aliphatic aldehydes can be employed. The reaction provided the first catalytic and enantioselective approach to chiral β-iodo Baylis-Hillman ester adducts.
