43192-34-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-3-methoxybenzaldehyde is used as a building block for the synthesis of various pharmaceuticals. Its unique chemical properties allow it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Bromo-3-methoxybenzaldehyde serves as an essential intermediate in the production of agrochemicals. Its incorporation aids in the creation of effective compounds for agricultural applications, enhancing crop protection and yield.
Used in Fine Chemicals Production:
4-Bromo-3-methoxybenzaldehyde is utilized as a crucial intermediate in the synthesis of fine chemicals. Its versatility in organic reactions facilitates the production of high-quality specialty chemicals for various applications.
Used in Dye Manufacturing:
4-BROMO-3-METHOXYBENZALDEHYDE is used as a key intermediate in the manufacturing of dyes. Its chemical structure imparts color and stability to the dyes, making it an important component in the textile and other colorant-dependent industries.
Used in Fragrance Industry:
4-Bromo-3-methoxybenzaldehyde is employed in the production of fragrances due to its strong, sweet, and floral odor. It contributes to the creation of various scent profiles in perfumes, cosmetics, and other fragranced products, enhancing their appeal and marketability.

InChI:InChI=1S/C8H7BrO2/c1-11-8-4-6(5-10)2-3-7(8)9/h2-5H,1H3

Upstream product

• 20035-32-9 4-bromo-3-hydroxy-benzaldehyde 
• 77-78-1 dimethyl sulfate 
• 90151-40-9 4-amino-3-methoxybenzaldehyde 
• 1148110-16-0 1-bromo-4-(bromomethyl)-2-methoxybenzene 
• 591-31-1 3-methoxy-benzaldehyde 
• 17100-63-9 methyl 4-bromo-3-methoxybenzoate 
• 19056-40-7 4-bromo-3-methoxyaniline 
• 704-13-2 5-formyl-2-nitrophenol 
• 80410-57-7 3-methoxy-4-nitrobenzaldehyde 
• 120315-65-3 4-bromo-3-methoxy-benzonitrile 
• 6971-51-3 3-methoxybenzyl alcohol 
• 932372-99-1 2-bromo-5-iodophenol 
• 755027-18-0 1-bromo-4-iodo-2-methoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 132040-97-2 1-Bromo-4-dimethoxymethyl-2-methoxy-benzene 
• 1089196-82-6 C₂₀H₁₈BrN₃O₂S 
• 1330753-51-9 1-(3-methoxy-4-bromophenyl)-7-(3-hydroxy-4-methoxyphenyl)heptan-3-one 
• 1352042-58-0 ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-methoxycinnamate 
• 1352042-63-7 ethyl (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-methoxycinnamate 
• 1352042-64-8 ethyl (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-hydroxycinnamate 
• 1352042-70-6 (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-methoxycinnamic acid 
• 1352042-71-7 (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-hydroxycinnamic acid 
• 1352042-54-6 (E)-ethyl 3-(4-bromo-3-methoxyphenyl)acrylate 
• 113081-51-9 2-(4-bromo-3-methoxy-phenyl)-ethylamine 
• 1428796-73-9 N-(4-bromo-3-methoxyphenethyl)acetamide 
• 1428796-07-9 (R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide 
• 1428796-81-9 ethyl 9-ethyl-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate 
• 1428796-82-0 9-ethyl-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylic acid 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

The present invention provides a compound of formula (Ia) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, solid forms, combinations of pharmacologically active agents, pharmaceutical compositions and methods of using such compounds and solid forms thereof to treat or prevent parasitic diseases, for example malaria.

Vanadium-Catalyzed Oxidative Intramolecular Coupling of Tethered Phenols: Formation of Phenol-Dienone Products

A mild and efficient method for the vanadium-catalyzed intramolecular coupling of tethered free phenols is described. The corresponding phenol-dienone products are prepared directly in good yields with low catalyst loadings. Electronically diverse tethered phenol precursors are well tolerated, and the catalytic method was effectively applied as the key step in syntheses of three natural products and a synthetically useful morphinan alkaloid precursor.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

A novel anti-Alzheimer agent inhibiting oligomerization and fibriliation of beta-amyloid protects neuronal cell from Aβ-induced cytotoxicity

The present invention relates to development of a novel treatment agent for Alzheimerandprime;s disease, having ability of protecting neural cells and inhibiting fibrosis and oligomerization of beta-amyloid. A compound of the present invention is capable of, while maintaining therapeutic effects on Alzheimerandprime;s disease, recovering ability of directly inhibiting oligomerized and fibrous amyloid beta, which is inherent activities of existing curcumin, thereby being useful as a novel inhibitor.COPYRIGHT KIPO 2017

PHARMACEUTICAL COMPOUNDS

This invention relates to compounds that inhibit or modulate the activity of Chk-1 kinase. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds.

Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of β-amyloid peptides and protects neuronal cells from β-amyloid-induced cytotoxicity

A series of novel J147 derivatives were synthesized, and their inhibitory activities against β-amyloid (Aβ) aggregation and toxicity were evaluated by using the oligomer-specific antibody assay, the thioflavin-T fluorescence assay, and a cell viability assay in the transformed SH-SY5Y cell culture. Among the synthesized J147 derivatives, 3j with a 2,2-dicyanovinyl substituent showed the most potent inhibitory activity against Aβ42 oligomerization (IC50 = 17.3 μM) and Aβ42 fibrillization (IC50 = 10.5 μM), and disassembled the preformed Aβ42 fibrils with an EC50 of 10.2 μM. Finally, we confirmed that 3j is also effective at preventing neurotoxicity induced by Aβ42-oligomers as well as Aβ42-fibrils.

A mild oxidation of deactivated naphthalenes and anthracenes to corresponding para-quinones by N-bromosuccinimide

A new method to synthesize 1,4-naphthoquinone and 9,10-anthraquinone from naphthalene and anthracene functionalized with either -CHO or -COOH groups, using N-bromosuccinimide (NBS) in aqueous N,N-dimethylformamide at 75-80 °C, has been developed. Further, -CN and -CONH2 functionalized naphthalenes and anthracenes can also be transformed into respective para-quinones in a one pot reaction, after successive acid hydrolysis and subsequent reaction with NBS. We believe that the present finding may serve as a valuable alternative to the classical approaches for the synthesis of polycyclic quinones from polyaromatic carbaldehydes through Dakin oxidation followed by further oxidation of the resulting hydroquinone by heavy metal oxides.

FSH RECEPTOR ANTAGONISTS

The invention relates to FSH receptor antagonist according to general formula (I) or a pharmaceutically acceptable salt thereof and to a pharmaceutical composition containing the same. The compounds can be used for the treatment and prevention of endometriosis, for the treatment and prevention of pre-menopausal and peri-menopausal hormone-dependent breast cancer, for contraception, and for the treatment of uterine fibroids and other menstrual-related disorders

Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of

The parent phenol of adapalene and its (E)-cinnamic acid analogue were found to induce cancer cell apoptosis but cause adverse systemic effects when administered to mice. In contrast, their respective 5-Cl- and 3-Cl-substituted analogues had their adverse

Synthesis and preliminary evaluation of curcumin analogues as cytotoxic agents

A series of curcumin analogues with different substituents at the 4-position of the phenyl group were synthesized and screened for in vitro cytotoxicity against a panel of human cancer cell lines. Several novel curcumin analogues, especially 32 and 34, exhibited selective and potent cytotoxic activity against human epidermoid carcinoma cell line A-431 and human glioblastoma cell line U-251, implying their specific potential in the chemoprevention and chemotherapy of skin cancer and glioma. The preliminary SAR information extracted from the results suggested that introduction of appropriate substituents to the 4′-positions could be a promising approach for the development of new cytotoxic curcumin analogues with special selectivity for A-431 and U-251 cell lines.