75513-55-2

Basic information

• Product Name: 1-diphenoxyphosphoryloxypyrrolidine-2,5-dione
• Synonyms: diphenyl succinimidyl phosphate; 1-[(diphenoxyphosphoryl)oxy]pyrrolidine-2,5-dione
• CAS NO: 75513-55-2
• Molecular Formula: C₁₆H₁₄NO₆P
• Molecular Weight: 347.2592
• Mol File: 75513-55-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 83-86 °C(lit.)
• Boiling Point: 454.1°Cat760mmHg
• Flash Point: 228.4°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 1.96E-08mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: ?20°C
• CAS DataBase Reference: 1-diphenoxyphosphoryloxypyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-diphenoxyphosphoryloxypyrrolidine-2,5-dione(75513-55-2)
• EPA Substance Registry System: 1-diphenoxyphosphoryloxypyrrolidine-2,5-dione(75513-55-2)

Safety Data

• Hazardous Substances Data: 75513-55-2(Hazardous Substances Data)

Usage

General Description

1-diphenoxyphosphoryloxypyrrolidine-2,5-dione, commonly known as DFP, is a chemical compound that contains a pyrrolidine ring and phosphoramide group. It is often used as a nerve agent to disrupt the transmission of nerve signals and can be toxic when ingested, inhaled, or absorbed through the skin. DFP is a potent inhibitor of acetylcholinesterase, an enzyme responsible for breaking down the neurotransmitter acetylcholine, leading to a buildup of acetylcholine at nerve junctions and overstimulation of the nervous system. Due to its toxic and potentially lethal effects, DFP is classified as a chemical warfare agent and is regulated under international law. Additionally, DFP has potential use as an organic phosphorus pesticide. It is important to handle and store DFP with caution and follow proper safety protocols to minimize the risk of exposure.

InChI:InChI=1/C16H14NO6P/c18-15-11-12-16(19)17(15)23-24(20,21-13-7-3-1-4-8-13)22-14-9-5-2-6-10-14/h1-10H,11-12H2

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 1499-21-4 Diphenylphosphinic chloride 
• 10359-36-1 4-nitro-phenyl diphenyl phosphate 
• 2524-64-3 chlorophosphoric acid diphenyl ester 

Downstream Products

• 60722-88-5 N-hydroxysuccinimide ester of 4-<(carbobenzyloxy)amino>butyric acid 
• 76944-94-0 N-benzyloxycarbonyl-5-aminovaleric acid succinimide ester 
• 53733-98-5 N-hydroxysuccinimide ester of 6-{[(benzyloxy)carbonyl]amino}hexanoic acid 
• 30189-36-7 N,N'-di-t-butyloxycarbonyl-(S)-lysine N-hydroxysuccinimide ester 
• 960155-98-0 docetaxel 2'-succinic ester 
• 1001441-14-0 paclitaxel-glutaric acid-N-hydroxysuccinimide 
• 245110-80-9 paclitaxel-2’-succinyl-NHS 
• 15676-16-1 N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide 
• 3401-36-3 (N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester 
• 3392-05-0 Boc-Ala-O-N-hydroxysuccinimide 

Relevant articles and documents

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Polymeric micelles with water-insoluble drug as hydrophobic moiety for drug delivery

The hydrophobic block of polymeric micelles formed by amphiphilic copolymers has no direct therapeutical effect, and the metabolites of these hydrophobic segments might lead to some unexpected side effects. Here the hydrophobic core of polymeric micelles