75516-83-5

Upstream product

• 917-54-4 methyllithium 
• 70361-62-5 2-(Benzylidenamino)propensaeure-methylester 
• 89891-09-8 Imidazole-1-carboxylic acid (S)-2-methoxycarbonyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl ester 
• 100-52-7 benzaldehyde 
• 40216-75-9 N-benzylidene-L-serine methyl ester 
• 15681-48-8 lithium dimethylcuprate * lithium iodide 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 75517-03-2 methyl 4-ethoxycarbonyl-2-ethyl-3,5-diphenyl-3-pyrroline-2-carboxylate 
• 1431318-91-0 (1'S,2S,3'R,3a'S,7a'R)-methyl 3'-ethyl-5,7'-dioxo-1'-phenyl-1',2',3',3a',4,5,7',7a'-octahydro-3H-spiro[furan-2,4'-isoindole]-3'-carboxylate 
• 1415421-68-9 (1R,3R)-methyl 1-ethyl-4,9-dihydroxy-3-phenyl-2,3-dihydro-1H-benzo[f]isoindole-1-carboxylate 
• 1067979-31-0 4-tert-butyl 2-methyl 2-ethyl-5-phenylpyrrolidine-2,4-dicarboxylate 
• 1067979-94-5 dimethyl 2-ethyl-3-methyl-5-phenylpyrrolidine-2,4-dicarboxylate 

Relevant academic research and scientific papers

Synthesis of N-(Arylmethylene)dehydroalanine Methyl Esters and Their Application as Building Blocks in the Syntheses of Amino Acids

Starting with serine, the useful N-(arylmethylene)dehydroalanine methyl esters 6 have been synthesized.These compounds react with nucleophiles in a Michael fashion to give the amino acid derivatives 8 and 9. - Hence, the Michael addition of diorganocopper (I) reagents as C nucleophiles to 6a yielding 9 provides a new method of amino acid synthesis.The extent of the desired 1,4 addition varies with the nature of the reagent and is dependent on several experimental parameters, viz: type of Cu (I) salt, complexing ligands, solvent, and temperature.