75527-39-8

Usage

Molecular structure

Consists of a benzyl group, a fluorophenyl group, and a piperidin-4-ol group.

Chemical classification

Is a piperidine derivative.

Potential pharmacological properties

Has potential as a therapeutic agent for various medical conditions.

Medical applications

Studied for its potential use in pain management, psychiatric disorders, and neurological diseases.

Presence of fluorophenyl group

May confer specific physiological or biological activity to the compound.

Importance in research

The specific activity and potential medical applications make it a valuable target for further research and development.

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 1073-06-9 3-fluorobromobenzene 
• 17318-03-5 bromo(3-fluorophenyl)magnesium 

Downstream Products

• 75527-53-6 1-methyl-3-hydroxymethyl-3-(m-fluorophenyl)pyrrolidine 
• 75527-49-0 1-ethoxycarbonyl-4-(m-fluorophenyl)-3,4-epoxypiperidine 
• 75527-51-4 1-ethoxycarbonyl-3-formyl-3-(m-fluorophenyl)pyrrolidine 
• 75527-47-8 1-ethoxycarbonyl-4-(m-fluorophenyl)-1,2,5,6-tetrahydropyridine 
• 75527-62-7 [3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetyl chloride 
• 75527-60-5 [3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetic acid 
• 75527-58-1 1-methyl-3-cyanomethyl-3-(m-fluorophenyl)pyrrolidine 
• 75527-56-9 1-methyl-3-chloromethyl-3-(m-fluorophenyl)pyrrolidine 
• 75527-41-2 1-benzyl-4-(m-fluorophenyl)-1,2,5,6-tetrahydropyridine 

Relevant academic research and scientific papers

HEPATITIS B ANTIVIRAL AGENTS

The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists

Melanin concentrating hormone (MCH) is an important mediator of energy homeostasis and plays a role in metabolic and CNS disorders. The modeling-supported design, synthesis and multi-parameter optimization (biological activity, solubility, metabolic stability, hERG) of novel quinazoline derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss with a lead compound from this series is exemplified. Clusters of refined hMCHR1 homology models derived from the X-ray structure of the β2-adrenergic receptor, including extracellular loops, were developed and used to guide the design.

4-ARYLMORPHOLIN-3-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF

The invention relates to compounds corresponding to formula (I): in which: Ar represents a mono- or disubstituted phenyl; R1 represents an unsubstituted or substituted phenyl; R2 represents: a pyridyl; an unsubstituted or substituted phenyl; a benzyl that is unsubstituted or substituted on the phenyl; R2 may moreover represent: a heterocyclic radical; R3 represents various values. The invention also comprises methods for the compounds preparation, formulations comprising them and therapeutic applications thereof.

INDOLE DERIVATIVE AND USE FOR TREATMENT OF CANCER

The present invention relates to a compound represented by the formula (I’) wherein A is a benzene ring optionally having substituents, R1, R2a and R3 are each a hydrogen atom, a hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, R1 and R2a may form a ring via X, when R1 and R2a form a ring via X, R1 and R2a are each a bond or a divalent C1-5 acyclic hydrocarbon group optionally having substituents, and X is a bond, an oxygen atom, an optionally oxidized sulfur atom or an imino group optionally having a substituent, provided that R1, R2a and X are not bonds at the same time, or a salt thereof, and an agent for inhibiting kinase (phosphorylation enzyme), which contains this compound or a prodrug thereof. The compound of the present invention has an inhibitory activity against kinase such as a vascular endothelial growth factor receptor (VEGFR) and the like, and is useful as an agent for the prophylaxis or threatment of cancer and the like.

Piperidine derivatives having renin inhibiting activity

Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I wherein R1, R2, R3, R4, Q, X, Z, m and n are as described herein.

1,3,8-TRIAZASPIRODECANE-4-ONES, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHOD OF USE THEREOF

Compounds of the formula STR1 where Q is defined hereinafter and X and Y are hydrogen, halogen, lower alkyl, nitro are useful as neuroleptics.

Studies on Psychotropic Agents. VI. Synthesis of 1'-Methylspiro-3-one and Related Compounds

The title compounds (19) were synthesized by rearrangement of the 1-ethoxycarbonyl-4-aryl-3,4-epoxypiperidines (7) to give the 3-aryl-3-formylpyrrolidine derivatives (12) for pharmacological testing.Compound (19b) exhibited moderate central nervous system