40451-67-0

Usage

Also known as

Succinimide (a common name for the compound)

Structure

Cyclic amide with a five-membered ring, including a carbonyl group and a nitrogen atom (described as a cyclic compound with specific functional groups)

Applications

Production of pharmaceuticals, as a plasticizer, as a pesticide, and as a chemical intermediate in organic chemistry reactions (indicating its versatility in various industries)

Properties

Studied for its potential anti-inflammatory and anticonvulsant properties (suggesting possible uses in medicine)

InChI:InChI=1/C5H8N2O2/c6-5(9)7-3-1-2-4(7)8/h1-3H2,(H2,6,9)

Upstream product

• 2609-10-1 grateloupine 
• 167417-31-4 1-(N-chloroacetylcarbamoyl)-2-pyrrolidinone 
• 57-13-6 urea 
• 56-12-2 4-amino-n-butyric acid 
• 590-28-3 potassium cyanate 
• 75548-99-1 tetrahydro-2H-1,3-diazepine-2,4(3H)-dione 
• 616-45-5 2-pyrrolidinon 
• 598-55-0 methyl carbamate 
• 1411984-04-7 methyl 4-cyanamidobutanoate 

Downstream Products

• 133861-85-5 BTMI 
• 103772-04-9 N-carbamoyl-2-methoxypyrrolidine 

Relevant academic research and scientific papers

Cyclization of 4-ureidobutanoic acids in acetic anhydride

A simple method is proposed for synthesizing 1-carbamoyl-2-pyrrolidones by cyclization of 4-ureidobutanoic acids in acetic anhydride.

BIOLOGICALLY ACTIVE ACETOGENINS FROM STEM BARK OF ASIMINA TRILOBA

In continuing our research with cytotoxic and pesticidal components from the stem bark of the North American paw paw, Asimina triloba, the novel cytotoxic monotetrahydrofuran Annonaceous acetogenis, cis- and trans-annonacin-A-one, cis- and trans-gigantetrocinone and cis-isoannonacin, in addition to the known compounds, trans-isoannonacin and squamolone, have been identified.Brine shrimp lethalty testing was used to direct the fractionation.The structures were elucidated by spectral analysis and/or chemical synthesis.These acetogenins have potent cytotoxicities against the human tumor cell lines of A-549 (lung carcinoma), MCF-7 (breast carcinoma) and HT-29 (colon adenocarcinoma). Key Word Index: Asimina triloba; Annonaceae; stem bark; acetogenins; cis- and trans-annonacin-A-one; cis- and trans-gigantetrocinone; cis- and trans-isoannonacin; squamolone.

Dibutylphosphate (DBP) mediated synthesis of cyclic N,N′- disubstituted urea derivatives from amino esters: A comparative study

The N,N′-disubstituted urea derivatives such as amino acid hydantoins and dihydrouracil derivatives were prepared starting from natural and unnatural amino acid esters using dibutylphosphate (DBP). During the attempted synthesis of N-heterocycles with larger than six-membered rings containing the N,N′-disubstituted urea functionalities, three unexpected products namely squamolone, N-methyl pyrrolidine-2-one, and diketopiperazine were isolated.

A biogenetically inspired heterodimerization approach to the synthesis of the core structure of the alkaloid fissoldhimine

A biogenetically inspired heterodimerization reaction of N-substituted 2-pyrroline equivalents leads to the tricyclic core of the alkaloid fissoldhimine. Thus, pyrrolidin-2-ol derivatives, in which the nitrogen atom is substituted either with urea or thio

Process for preparing derivatives of isopropenyl-α, α-dimethylbenzyl isocyanate

A process for preparing blocked derivatives of m- or p- isopropenyl-α,α-dimethylbenzyl isocyanates, comprising reacting a meta- or a para-isopropenyl-α,α-dimethylbenzyl carbamate ester with hydroxy functional blocking group, such as hydroxyethylene-ethyleneurea, hydroxyethylenepropylene urea, dialkylaminoethanol and dialkylamino propanol

Chemical constituents of Polyalthia suberosa. A one-pot synthesis of 1-carbamoylpyrrolidin-2-one, a constituent of the plant

1-Carbamoylpyrrolidin-2-one (1) and tetrahydropalmatine (3) have been isolated from the bark of Polyalthia suberosa. A simple one-step synthesis of 1 is reported.

Synthesis of carbocyclic nucleosides from 2-azabicyclo[2.2.1]hept-5-en-3-ones: Sodium borohydride-mediated carbon-nitrogen bond cleavage of five- and six-membered lactams

Various carbocyclic ribofuranosyl nucleosides were stereoselectively synthesized through a small number of steps from 2-azabicyclo[2.2.1]hept-5-en-3-ones by the use of sodium borohydride-mediated C-N bond cleavage as a key step. Ready availability of a no

1,3-Diazepinones. 2. The Correct Structure of Squamolone as 1-Carbamoyl-2-pyrrolidinone and Synthesis of Authentic Perhydro-1,3-diazepine-2,4-dione

The natural product squamolone,previously reported as 4-oxoperhydro-1,3-diazepin-2-one (1), was found to be instead 1-carbamoyl-2-pyrrolidinone (2).An unequivocal synthesis of the diazepinedione 1 starting from glutaric acid monoamide (6) produced the desired compound in five steps.Diborane reduction of 1 yielded the known perhydro-1,3-diazepin-2-one (10, tetramethyleneurea), confirming the seven-membered-ring structure of 1.A detailed analysis of the IR, NMR, and mass spectra of squamolone (2) and its isomer 1 is presented.A one-step synthesis of squamolone (2) starting with 4-aminobutyric acid 3 is reported.