7556-92-5Relevant academic research and scientific papers
New method for the direct electrophilic amination of aromatic compounds and its use in the annelation of the pyrimidine ring
Aksenov,Lyakhovnenko,Kugutov
experimental part, p. 1262 - 1265 (2011/10/09)
A method has been developed for the synthesis of aromatic amines by the amination of the corresponding aromatic compounds using sodium azide in PPA. A method for the synthesis of quinazolines and benzo[h]quinazolines using this reaction and the subsequent reaction of the intermediates with 1,3,5-triazines has been developed.
A microwave improvement in the synthesis of the quinazoline scaffold
Chilin, Adriana,Marzaro, Giovanni,Zanatta, Samuele,Guiotto, Adriano
, p. 3229 - 3231 (2008/02/02)
A rapid and efficient microwave-assisted protocol is described that greatly improves a recent synthetic method developed for quinazoline synthesis. The synthetic protocol is based on the use of cycles of microwave irradiation. The optimization process is reported and the experimental results are compared with those of the conventional synthetic route.
A new access to quinazolines from simple anilines
Chilin, Adriana,Marzaro, Giovanni,Zanatta, Samuele,Barbieri, Vera,Pastorini, Giovanni,Manzini, Paolo,Guiotto, Adriano
, p. 12351 - 12356 (2007/10/03)
A new synthetic pathway to quinazolines is described. This new method uses hexamethylenetetramine in TFA and potassium ferricyanide in aqueous ethanolic KOH, starting from simple N-protected anilines. The method affords substituted quinazolines with high
