755729-83-0

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 136024-60-7 1-(tert-butyl) 2-methyl (2S,4R)-4-(benzyloxy)pyrrolidine-1,2-dicarboxylate 
• 109953-95-9 tert-butyl (2S,4R)-4-(benzyloxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 136024-61-8 (4R)-benzyloxy-(2S)-formylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 75-36-5 acetyl chloride 

Downstream Products

• 1189757-14-9 (2S)-methyl-2-[(2S,4R)-4-(benzyloxy)-2-(dimethoxyethyl)pyrrolidin-1-yl]-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acetate 
• 869649-42-3 (1S,2S,4R,8R,9R)-7-oxo-4-(toluene-4-sulfonyloxy)-10,11-dioxa-6-aza-tricyclo[6.2.1.0]undecane-9-carboxylic acid methyl ester 
• 869649-15-0 (1S,2S,4R,8R,9R)-4-benzyloxy-7-oxo-10,11-dioxa-6-aza-tricyclo[6.2.1.0]undecane-9-carboxylic acid methyl ester 
• 869649-09-2 (4R,5R)-5-((2S,4R)-4-Benzyloxy-2-dimethoxymethyl-pyrrolidine-1-carbonyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester 
• 869649-22-9 (4S,5S)-5-((2S,4R)-4-Benzyloxy-2-dimethoxymethyl-pyrrolidine-1-carbonyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of a constrained tricyclic scaffold based on trans-4-hydroxy-L- proline

Drug discovery research has taken advantage of peptidomimetic chemistry in order to achieve new leads possessing structural and functional characteristics of bioactive peptides together with enhanced metabolic resistance towards proteases. Herein is repor