75574-69-5Relevant academic research and scientific papers
Isoxazole compounds useful for the prophylaxis or treatment of nervous diseases
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, (2008/06/13)
Isoxazole compounds having the following general formula: STR1 wherein R1 represents an optionally substituted aryl group or aromatic heterocyclic group; R2 represents a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, an alkoxy group, a cyano group, a carboxyl group, an alkanoyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group; R3 represents an optionally substituted amino group or a saturated heterocyclic group; X represents an oxygen atom or a sulfur atom; and n is an integer of from 2 to 6. These compounds have excellent monoamine oxidase inhibitory activity and are useful as a therapeutic agent or a preventive agent against nervous diseases such as depression.
1,2-dioxetane derivatives, intermediates for syntheses thereof and methods of producing the intermediates
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, (2008/06/13)
A chemiluminescent 1,2-dioxetane derivative having a formula (I): STR1 wherein R1 and R4 each represent, individually, hydrogen, an alkyl group, an alkoxyl group, a hydroxyl group, or --OSi(R9 R10 R11) in which R9, R10 and R11 each represent an alkyl group; R2, R3, R5 and R6 each represent, individually, hydrogen or an alkyl group, provided that R2, R3, R5 and R6 each cannot be hydrogen at the same time, and that R2 and R3, and R5 and R6, each taken together, can form a cycloalkyl group; R7 represents an alkyl group; R8 represents hydrogen, an alkoxyl group, a phosphate salt group, or --OSi(R9 R10 R11); intermediates for synthesizing the above 1,2-dioxetane derivative; and methods of producing the intermediates are provided.
