75590-65-7Relevant articles and documents
SIMPLE METHOD FOR THE PREPARATION OF 1-SUBSTITUTED ISATINS
Radul, O. M.,Zhungietu, G. I.,Rekhter, M. A.,Bukhanyuk, S. M.
, p. 286 - 288 (1983)
The use of potassium carbonate in dimethylformamide (DMF) makes it possible to carry out the N-alkylation of isatins with alkyl bromides and iodides and acyl chlorides at room temperature and with alkyl chlorides at elevated temperatures (70-80 deg C) without ring opening.The previously inaccesible N-(2-chloroethyl)isatins were obtained by alkylation of isatin with 1,2-dichloroethane.The condensation of isatins with 1,3-dichloro-2-butene takes place only at the chlorine atom in allyl position of the latter.