Chemistry of Heterocyclic Compounds p. 286 - 288 (1983)
Update date:2022-08-02
Topics:
Radul, O. M.
Zhungietu, G. I.
Rekhter, M. A.
Bukhanyuk, S. M.
The use of potassium carbonate in dimethylformamide (DMF) makes it possible to carry out the N-alkylation of isatins with alkyl bromides and iodides and acyl chlorides at room temperature and with alkyl chlorides at elevated temperatures (70-80 deg C) without ring opening.The previously inaccesible N-(2-chloroethyl)isatins were obtained by alkylation of isatin with 1,2-dichloroethane.The condensation of isatins with 1,3-dichloro-2-butene takes place only at the chlorine atom in allyl position of the latter.
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