756474-36-9

Usage

Uses

Used in Pharmaceutical Industry:
CHEMBRDG-BB 4022334 is used as a pharmaceutical compound for its potential therapeutic effects and interactions within biological systems. Its steroidal structure may contribute to its efficacy in treating various medical conditions.
Used in Medical Research:
In the field of medical research, CHEMBRDG-BB 4022334 is utilized as a research tool to study the mechanisms of action and potential applications of steroidal compounds. This can aid in the development of new drugs and therapies based on a better understanding of their interactions with biological targets.
Used in Biological Research:
CHEMBRDG-BB 4022334 serves as a valuable compound in biological research, where it can be employed to investigate the roles and functions of steroids in biological processes. This may lead to insights into the development of novel treatments and a deeper comprehension of the underlying biology.

InChI:InChI=1/C11H17NO/c1-9(2)12-8-10-6-4-5-7-11(10)13-3/h4-7,9,12H,8H2,1-3H3

Upstream product

• 135-02-4 ortho-anisaldehyde 
• 13033-50-6 N-(2-methoxybenzylidene)isopropylamine 
• 6609-56-9 2-methoxy-benzonitrile 
• 67-63-0 isopropyl alcohol 
• 837387-80-1 isopropylidene-(2-methoxy-benzyl)-amine 
• 6850-57-3 2-methoxybenzylamine 
• 837387-87-8 (1,1-dimethyl-2-nitro-butyl)-(2-methoxy-benzyl)-amine 

Relevant academic research and scientific papers

Catalytic Asymmetric Synthesis of N-Chiral Amine Oxides

Direct asymmetric synthesis of N-chiral amine oxides was accomplished (up to 91:9 e.r.) by means of a bimetallic titanium catalyst. A hydroxy group situated at the γ-position of the N stereocenter enables the desired N-oxidation through dynamic kinetic resolution of the trivalent amine substrates. The method was further extended to the kinetic resolution of racemic γ-amino alcohols with a preexisting stereocenter, giving an important class of enantioenriched (up to 99.9:0.1 e.r.) building blocks that are otherwise difficult to synthesize.

Ruthenium-catalyzed transfer hydrogenation of nitriles: Reduction and subsequent N-monoalkylation to secondary amines

The selective synthesis of amines continues to be of importance because of their application in the bulk and fine chemical industries. Herein, domino ruthenium-catalyzed transfer hydrogenation of nitriles with subsequent N-monoalkylation by using alcohols is described. With this novel approach, various nitriles were reductively N-monoalkylated in excellent yields. A simple method for the synthesis of secondary amines starting directly from nitriles by using a ruthenium catalyst is described. With this novel domino system, various nitriles were reduced and subsequently N-monoalkylated in excellent yields (up to 99 %). In addition to isopropanol, other alcohols were also used as a reductant and N-monoalkylation reagent. Copyright

Scope and limitations of the nitro-Mannich reaction for the stereoselective synthesis of 1,2-diamines

(Chemical Equation Presented) The acetic acid-promoted addition of lithium nitropropanate and the Lewis acid-catalyzed [Sc-(OTf)3, Cu(OTf) 2, or Ti(OiPr)4] addition of trimethylsilyl nitropropanate to a range of heteroaromatic and simple aliphatic aldimines gave anti-rich (～3-19:1) β-nitroamines in >95% yields as the kinetic products. It was found that a nonpolar N-imine protecting group was essential for reactivity with the o-methoxybenzyl (OMB) group giving better selectivities and yields than p-methoxybenzyl (PMB) or p-methoxyphenyl (PMP) in the Lewis acid-catalyzed addition reactions. Reduction with SmI2, treatment with COCl 2, followed by OMB deprotection gave diastereomerically pure cis-imidazolidinones in 55-79% overall yield from imine. Preliminary results have shown that acetic acid can catalyze the reaction of N-OMB-benzylideneamine with nitropropane, used as solvent, to give the thermodynamically more stable syn-β-nitroamine product.