756485-04-8

Upstream product

• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 139545-04-3 (E)-(S)-4-tert-Butoxycarbonylamino-5-phenyl-pent-2-enoic acid 
• 10512-93-3 Z-Val-ONp 
• 3182-95-4 L-Phenylalaninol 
• 116246-06-1 (E)-(S)-4-tert-Butoxycarbonylamino-5-phenyl-pent-2-enoic acid ethyl ester 
• 148743-43-5 N-benzyloxycarbonyl-L-valyl-L-phenylalaninol 

Downstream Products

• 129467-49-8 {(S)-1-[(1S,2S,3S,4S)-1-Benzyl-4-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-2,3-dihydroxy-5-phenyl-pentylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester 
• 129467-48-7 A-75925 
• 194020-70-7 [(S)-1-((S)-1-Benzyl-2,2-dimethoxy-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester 
• 134805-50-8 (2S,3R,4R,5S)-2,5-bis(N-valinylamino)-3,4-dihydroxy-1,6-diphenylhexane 
• 194020-73-0 (S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,2-dimethoxy-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-ethyl}-ureido)-3-phenyl-propionic acid tert-butyl ester 
• 1027552-35-7 (S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,2-dimethoxy-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-ethyl}-ureido)-3-phenyl-propionic acid methyl ester 
• 194020-71-8 (S)-2-Amino-N-((S)-1-benzyl-2,2-dimethoxy-ethyl)-3-methyl-butyramide 
• 148743-44-6 4(S)-<valyl>amino>-5-phenyl-2(E)-pentenoic acid ethyl ester 

Relevant academic research and scientific papers

PROCESS FOR PRODUCING PEPTIDYL ALDEHYDES

The present invention provides a method of producing a peptidyl aldehyde derivative of the formula (II) wherein A is acyl derived from amino acid, and R1 and R2 are different and one is hydrogen atom and the other is optionally subst

Inhibitors of β-amyloid protein production

This invention relates to compounds and pharmaceutical compositions, and methods for inhibiting or preventing the amyloid protein deposits in the brain which are associated with Alzheimer's disease and aged Down's syndrome patients. More particularly, it relates to the treatment of Alzheimer's disease.

Use of ozonolysis in the synthesis of C-terminal peptide aldehydes on solid support

A new strategy for the synthesis of peptide aldehydes on solid support is presented. Reaction of a N-protected aminoaldehyde with caboethoxymethylene triphenylphosphorane yielded an α-β-unsaturated δ- amino derivative. After saponification, the resulting α-β-unsaturated δ- aminoacid was anchored to a solid support by an ester linkage (Merrifield resin) or by an amide linkage (MBHA, Expansin). After elongation of the peptide chain, ozonolysis yielded quite pure C-terminal peptide aldehydes in a good yield with no detectable racemization of the C-terminal residue.

Solid Phase Synthesis of C-Terminal Peptide Aldehydes

Peptides with C-terminal aldehydes (PAs) are of interest due to their inhibitory properties toward numerous classes of proteolytic enzymes. In this paper, we describe and compare two novel approaches for the preparation of PAs by solid phase synthesis, on

Vanadium(II)- and Niobium(III)-Induced, Diastereoselective Pinacol Coupling of Peptide Aldehydes to Give a C2-Symmetrical HIV Protease Inhibitor

Peptide aldehydes 15a-c are prepared without epimerization from enantiomerically pure (S)-α-amino acids (Scheme 3).Reductive pinacol homocoupling of 15a-c, induced by vanadium complex 11 or niobium complex 16 in refluxing THF, yields C2-symmetr

Improved solid phase synthesis of C-terminal peptide aldehydes

A new linker based on the Weinreb amide was developed in order to synthesize from peptidyl-resin the corresponding aldehydic peptides by reduction with LiAlH4.This new reaction was tested with N-protected amino-residues and with tripeptides to obtain the

Inhibitors of HIV-1 proteinase containing 2-heterosubstituted 4-amino-3- hydroxy-5-phenylpentanoic acid: Synthesis, enzyme inhibition, and antiviral activity

A convenient procedure for the synthesis of 2-heterosubstituted statine derivatives as novel building blocks in HIV-protease inhibitors has been developed. The synthesis starts with protected L-phenylalaninols, which were converted to γ-amino α,β-unsatura