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Usage

Uses

Used in Organic Synthesis:
(3Z,5S)-3-(1-Hydroxyethylidene)-5-[(S)-1-methylpropyl]-2,4-pyrrolidinedione is used as a key intermediate in organic synthesis for the development of various chemical compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (3Z,5S)-3-(1-Hydroxyethylidene)-5-[(S)-1-methylpropyl]-2,4-pyrrolidinedione is utilized as a starting material or building block for the synthesis of new drugs and medicinal agents. Its unique structure and potential biological activity make it a valuable component in drug discovery and development processes.

Upstream product

• 62972-98-9 (2S,3S)-N-acetoacetylisoleucine methyl ester 
• 2577-46-0 L-isoleucine methyl ester 

Relevant academic research and scientific papers

Further Reactions of t-Butyl 3-Oxobutanthioate and t-Butyl 4-Diethylphosphono-3-oxobutanthioate: Carbonyl Coupling Reactions, Amination, Use in The Preparation of 3-Acyltetramic Acids and Application to The Total Synthesis of Fuligorubin A.

Key words: Acyltetramic acid; Phosphonate; Wadsworth-Emmons; Dieckmann cyclisation; Fuligorubin A. Abstract: The use of t-butyl-3-oxobutanthioate (1) and t-butyl 4-diethylphosphono-3-oxobuthanthioate (2) for the preparation of homologated derivatives suitable for amination in the presence of silver(I) trifluoroacetate to afford the corresponding β-ketoamides is discussed.In particular Wadsworth-Emmons coupling reactions of (2) with various carbonyl compounds gave good yields of E-substituted products.Many of the β-ketoamides were shown to be suitable precursors for 3-acyltetramic acids using a Dieckman cyclisation with tetra-n-butyl ammonium fluoride as the cyclising base.These new reactions were applied to the total synthesis of the polyene 3-acyltetramic acid fuligorubin A.