756525-95-8

Basic information

• Product Name: H2N-PEG2-tBu
• Synonyms: H2N-PEG2-tBu;tert-Butyl 9-AMino-4,7-dioxanonanoate (H2N-PEG2-tBu) tert-butyl 9-AMino-4,7-dioxanonanoate;3-[2-(2-Aminoethoxy)ethoxy]propanoic acid 1,1-dimethylethyl ester;H2N-PEG2-CH2CH2COOtBu;Amino-PEG2-t-butyl ester;Amino-PEG3-t-butyl ester;H2N-PEG2-CH2CH2COOtBu;Amino-PEG2-acid -t-Butyl ester
• CAS NO: 756525-95-8
• Molecular Formula: C₁₁H₂₃NO₄
• Molecular Weight: 233.30462
• Product Categories: PEG-COOtBu
• Mol File: 756525-95-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 313.7±22.0 °C(Predicted)
• Appearance: /
• Density: 1.014±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.74±0.10(Predicted)
• CAS DataBase Reference: H2N-PEG2-tBu(CAS DataBase Reference)
• NIST Chemistry Reference: H2N-PEG2-tBu(756525-95-8)
• EPA Substance Registry System: H2N-PEG2-tBu(756525-95-8)

Safety Data

• Hazardous Substances Data: 756525-95-8(Hazardous Substances Data)

Usage

Description

Amino-PEG2-t-butyl ester is a PEG linker containing an amino group with a t-butyl protected carboxyl group (Boc).The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

3-[2-(2-Aminoethoxy)Ethoxy]Propanoic Acid 1,1-Dimethylethyl Ester is used as reactant in the synthesis of self-localizing ligands that control spatial location of proteins in living cells.

Upstream product

• 1938057-43-2 tert-butyl 3-(2-(2-iodoethoxy)ethoxy)propanoate 
• 1271728-79-0 tert-butyl 3-(2-(2-azidoethoxy)ethoxy)propanoate 
• 1663-39-4 tert-Butyl acrylate 
• 1629676-61-4 3-(2-(2-(2-(dibenzylamino)ethoxy)ethoxy))tert-butyl propionate 
• 1629676-51-2 C₁₉H₂₅NO₆ 
• 850090-13-0 9-(p-toluenesulfonyloxy)-3,6-diocanonanoic acid tert-butyl ester 
• 133803-81-3 2-methyl-2-propanyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate 

Downstream Products

• 1374666-26-8 C₁₂H₁₇NO₆ 
• 756525-98-1 3-(2-{2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy}ethoxy)propanoic acid 
• 1374666-27-9 C₂₄H₂₉N₃O₇ 
• 1374666-25-7 C₂₇H₃₄N₄O₈ 
• 1374677-38-9 C₃₀H₄₇N₅O₁₃S 
• 1037589-69-7 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-{2-[2-(3-oxo-3-{4-[3-oxo-3-(2-oxoazetidin-1-yl)propyl]phenylamino}propoxy)ethoxy]ethyl}propanamide 

Relevant articles and documents

TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT

The present invention relates to a target protein degradation-inducing Degraducer, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases related to EED, EZH2, or PRC2 comprising same as an active ingredient. A novel compound represented by formula 1, according to the present invention is a Degraducer compound that induces degradation of a target protein, i.e., embryonic ectoderm development (EED) or polycomb repressive complex 2 (PRC2), utilizing cereblon E3 ubiquitin ligase, von Hippel-Lindau tumor suppressor (VHL) E3 ubiquitin ligase, mouse double minute 2 homolog (MDM2) E3 ubiquitin ligase, and cellular inhibitor of apoptosis protein 1 (cIAP) E3 ubiquitin ligase, wherein the compound has an aspect of remarkably achieving target protein degradation-inducing activity through a ubiquitin proteasome system (UPS), and therefore there is a useful effect in that it is possible to provide a pharmaceutical composition for preventing or treating diseases or conditions related to a target protein, and a functional health food composition for preventing or improving same, comprising said compound as an active ingredient.

CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP

Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE

What provided is the conjugation of cytotoxic to a cell-binding molecule with a bis-linker(dual-linker) as shown in Formula (I). It provides bis-linkage methods of making a conjugate of a cytotoxic drug molecule to a cell-binding agent in a specific manner. It also relates to application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease.