1629676-61-4

Basic information

• Product Name: 3-(2-(2-(2-(dibenzylamino)ethoxy)ethoxy))tert-butyl propionate
• Synonyms: 3-(2-(2-(2-(dibenzylamino)ethoxy)ethoxy))tert-butyl propionate
• CAS NO: 1629676-61-4
• Molecular Weight: 413.557
• Mol File: 1629676-61-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 3-(2-(2-(2-(dibenzylamino)ethoxy)ethoxy))tert-butyl propionate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-(2-(2-(dibenzylamino)ethoxy)ethoxy))tert-butyl propionate(1629676-61-4)
• EPA Substance Registry System: 3-(2-(2-(2-(dibenzylamino)ethoxy)ethoxy))tert-butyl propionate(1629676-61-4)

Safety Data

• Hazardous Substances Data: 1629676-61-4(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 1663-39-4 tert-Butyl acrylate 
• 136533-09-0 N,N-dibenzyl-5-amino-3-oxapentan-1-ol 

Downstream Products

• 756525-95-8 2-methyl-2-propanyl 3-[2-(2-aminoethoxy)ethoxy]propanoate 
• 756525-98-1 3-(2-{2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy}ethoxy)propanoic acid 
• 1037589-69-7 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-{2-[2-(3-oxo-3-{4-[3-oxo-3-(2-oxoazetidin-1-yl)propyl]phenylamino}propoxy)ethoxy]ethyl}propanamide 
• 1374666-32-6 3-(2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethoxy)propanoic acid 
• 1610796-02-5 2,5-dioxopyrrolidin-1-yl-3 (2-(2-azidoethoxy)ethoxy)propanoate 
• 1312309-63-9 3-(2-(2-azidoethoxy)ethoxy)propanoic acid 

Relevant articles and documents

Scalable and cost-effective synthesis of a linker for bioconjugation with a peptide and a monoclonal antibody

An efficient, scalable, and cost-effective synthesis of a linker employed in a bioconjugation process with a peptide and a monoclonal antibody is presented. Several routes were investigated that resulted in the identification of a short synthesis to a key acid intermediate from inexpensive and readily available starting materials. The final coupling of this acid with an aniline to afford the desired linker has been optimized to produce multi-gram quantities of material for clinical studies. The very limited purifications needed for both intermediates and final product make this route amenable to scale. Georg Thieme Verlag Stuttgart New York.

CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP

Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.