756874-17-6

Usage

Molecular Weight

295.33

Structure

Contains an amino group (-NH2), a tert-butoxycarbonyl (Boc) group, and an ethoxyacetic acid backbone.

Boc Protecting Group

The presence of the Boc group allows for selective protection of the amino group during chemical reactions.

Reactivity

The Boc group can be removed under mild conditions, making it a useful building block in organic chemistry.

Applications

Used in the production of pharmaceuticals and other organic compounds due to its ability to participate in various chemical reactions.

Interactions

The presence of the amino group allows for potential interactions with other molecules, making it a valuable reagent in chemical research and drug development.

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 79-04-9 chloroacetyl chloride 
• 57561-39-4 methyl(2-hydroxyethyl)carbamic acid tert-butyl ester 
• 633698-71-2 [2-[[(1,1-dimethylethoxy)carbonyl]methylamino]ethoxy]acetic acid 1,1-dimethylethyl ester 

Relevant academic research and scientific papers

PCSK9 ANTAGONIST COMPOUNDS

Disclosed are compounds of Formula (A), or a pharmaceutically acceptable salt thereof: where A, X, R1, and R2 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula (I) or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.

One-pot, regiospecific assembly of (E)-benzamidines from δ- and γ-amino acids via an intramolecular aminoquinazolinone rearrangement

The efficient generation of novel, N-linked benzamidines resulting from a regiospecific rearrangement of quinazolinones is described. This methodology study explored reaction parameters including the effect of changing solvent and temperature, as well as varying electronic substituents on the structural core. The transformation was extensively optimized in terms of reaction conditions and scope, resulting in a protocol that consistently affords diversely functionalized amidines in high yield. The process permits regional structural derivatization that was previously inaccessible, and the multistep process was also reduced to a telescoped, five-step sequence that efficiently affords pharmacologically unique (E)-benzamidoamidines from N-BOC protected γ- and δ-amino acids.

HYDROXYMETHYL SUBSTITUTED DIHYDROISOXAZOLE DERIVATIVES USEFUL AS ANTIBIOTIC AGENTS

Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, (I) R1a is NH(C=W)R5 or (a); W is O or S; R2 and R3 are for example H or F; R1 is for example hydrogen, or halogen; R5 is selected from hydrogen, (2-6C)alkyl (optionally substituted); R6 and R7 are independently selected from hydrogen, and (1-4C)alkyl (optionally substituted); wherein R4 is either a hydroxymethyl substituent on C-4' of the isoxazoline ring; or R4 is a hydroxymethyl substituent on C-5' of the isoxazoline ring and the stereochemistry at C-5' of the isoxazoline ring and at C-5 of the oxazolidinone ring is selected, such that the compound of formula (I) is a single diastereomer; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.