75694-83-6Relevant academic research and scientific papers
CATALYSTS AND PROCESSES FOR THE HYDROGENATION OF AMIDES
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Paragraph 0248; 0249; 0250, (2014/06/24)
There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition metal catalyst in the presence or absence of a base under conditions for the reduction an amide bond. The presently described processes can be performed at low catalyst loading using relatively mild temperature and pressures, and optionally, in the presence or absence of a base or high catalyst loadings using low temperatures and pressures and high loadings of base to effect dynamic kinetic resolution of achiral amides.
A highly active catalyst for the hydrogenation of amides to alcohols and amines
John, Jeremy M.,Bergens, Steven H.
supporting information; experimental part, p. 10377 - 10380 (2011/12/04)
Amide-zing: The reaction between 2 equivalents of Ph2P(CH 2)2NH2 and cis-[Ru(CH3CN) 2(η3-C3H5)(cod)]BF4 (cod=1,5-cyclooctadiene) forms a highly active catalyst precursor for the selective hydrogenation of amides. The reaction proceeds with excellent atom economy, yield, and turnover numbers (TONs) under moderate reaction conditions. The technology offers a greener, practical approach to the use of metal hydride reagents commonly employed in both academia and industry. Copyright
