438187-35-0Relevant academic research and scientific papers
Preparation of 2-arylated-1,4-phenylenediamines by palladium-catalyzed cross-coupling reactions
Jensen, Anne Eeg,Knochel, Paul
, p. 122 - 128 (2007/10/03)
Protected 2-iodol-1,4-phenylenediamines were converted to the corresponding magnesium derivative by performing an iodine-magnesium exchange. After transmetalation with zinc bromide, a palladium(0)-catalyzed cross-coupling with various aryl iodides and 5-bromo-2-carbethoxyfuran furnished the expected cross-coupling products in 52-79% yield.
Preparation of Polyfunctional Heterocycles Using Highly Functionalized Aminated Arylmagnesium Reagents as Versatile Scaffolds
Lindsay, David M.,Dohle, Wolfgang,Jensen, Anne Eeg,Kopp, Felix,Knochel, Paul
, p. 1819 - 1822 (2007/10/03)
(Equation Presented) Functionalized Grignard reagents, derived from readily available o-iodoaniline derivatives and obtained via a straightforward iodine-magnesium exchange, can be used to prepare a wide range of polyfunctional indoles, quinolines, and quinazolinones.
