75703-25-2

Usage

Uses

Used in Organic Synthesis:
2,2,2-TRIFLUORO-1-P-TOLYL-ETHANONEOXIME is used as a synthetic building block for the creation of various organic compounds. Its unique structure, which includes a trifluoromethyl group and a p-tolyl group connected to an oxime, allows it to participate in a range of chemical reactions, facilitating the synthesis of complex molecules with potential applications in pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,2,2-TRIFLUORO-1-P-TOLYL-ETHANONEOXIME is used as a key intermediate in the development of new drugs. Its chemical properties make it suitable for the synthesis of novel drug candidates with potential therapeutic benefits. 2,2,2-TRIFLUORO-1-P-TOLYL-ETHANONEOXIME's reactivity and structural diversity enable the design of innovative molecules that can target specific biological pathways or receptors, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
2,2,2-TRIFLUORO-1-P-TOLYL-ETHANONEOXIME also finds application in the agrochemical industry, where it is utilized as a starting material for the synthesis of new pesticides or agrochemicals. Its unique structural features can be exploited to create molecules with enhanced biological activity, leading to the development of more effective and environmentally friendly products for crop protection and management.

InChI:InChI=1/C9H8F3NO/c1-6-2-4-7(5-3-6)8(13-14)9(10,11)12/h2-5,14H,1H3/b13-8-

Upstream product

• 394-59-2 2,2,2-trifluoro-1-(p-tolyl)ethanone 
• 106-38-7 para-bromotoluene 
• 108-88-3 toluene 

Downstream Products

• 87736-85-4 4-[3-(trifluoromethyl)-3H-diaziren-3-yl]toluene 
• 87736-82-1 3-(4-methylphenyl)-3-trifluoromethyldiaziridine 
• 87736-89-8 1-<<4-<3-(trifluoromethyl)-3H-diazirin-3-yl>benzoyl>oxy>-2,5-pyrrolidinedione 
• 85559-46-2 4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoic acid 
• 882429-59-6 2-(16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyl-hexadecahydro-cyclopenta[a]phenanthren-17-ylidene)-6-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-hex-5-enoic acid 2,2-dimethyl-propionyloxymethyl ester 
• 882429-62-1 2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyl-hexadecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-6-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-hexanoic acid 2,2-dimethyl-propionyloxymethyl ester 
• 92367-11-8 3-[4'-(bromomethyl)phenyl]-3-(trifluoromethyl)-3H-diazirine 
• 1400565-50-5 N,N'-(2,2'-(2,2'-(2,2'-(4-(2-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzamido)ethyl)-1,2-phenylene)bis(oxy)bis(ethane-2,1-diyl))bis(oxy)bis(ethane-2,1-diyl))bis(oxy)bis(ethane-2,1-diyl))bis(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzamide) 
• 1400565-40-3 N,N',N''-(2,2',2''-(2,2',2''-(2,2',2''-(benzene-1,3,5-triyltris(oxy))tris(ethane-2,1-diyl))tris(oxy)tris(ethane-2,1-diyl))tris(oxy)tris(ethane-2,1-diyl))tris(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzamide) 
• 1400565-39-0 N,N',N''-[benzene-1,3,5-triyltris(oxyethane-2,1-diyloxyethane-2,1-diyl)]tris{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzamide} 
• 1400565-49-2 N,N'-([4-(2-{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzamido}ethyl)-1,2-phenylene]bis(oxyethane-2,1-diyloxyethane-2,1-diyl))bis{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzamide} 

Relevant academic research and scientific papers

Engineering bromodomains with a photoactive amino acid by engaging 'Privileged' tRNA synthetases

Site-specific placement of unnatural amino acids, particularly those responsive to light, offers an elegant approach to control protein function and capture their fleeting 'interactome'. Herein, we have resurrected 4-(trifluoromethyldiazirinyl)-phenylalan

Rapid Mapping of Protein Interactions Using Tag-Transfer Photocrosslinkers

Analysing protein complexes by chemical crosslinking-mass spectrometry (XL-MS) is limited by the side-chain reactivities and sizes of available crosslinkers, their slow reaction rates, and difficulties in crosslink enrichment, especially for rare, transie

Ginkgolide derivatives for photolabeling studies: Preparation and pharmacological evaluation

The terpene trilactones (TTLs), ginkgolides and bilobalide, are structurally unique constituents of Ginkgo biloba extracts, which exhibit various neuromodulatory properties. Although the TTLs are believed to be responsible for some of these effects, the s

4-(1-Azi-2,2,2-trifluoroethyl)benzoic Acid, a Highly Photolabile Carbene Generating Label Readily Fixable to Biochemical Agents

The title compound is synthesized starting from either 4-bromobenzyl tert butyldimethylsilyl ether (5b) or 4-bromobenzyl tert-butyl ether (5c) or - most simply - from 4-bromotoluene (5a).In the first step Br was replaced by Li using n-butyllithium, then the organometallic compounds were converted into the respective trifluoroacetophenones 6a - c with N-trifluoroacetylpiperidine.The azi moiety (diazirine) was prepared from the oximes 7a - c via O-tosyloximes 8a - c plus ammonia yielding the diaziridines 9a - c and oxidation of the latter with Ag2O.Oxidation by permanganate - of the ethers after acidic cleavage - yields the title compound 12.On irradation (λ > 300 nm) 12 by elimination of N2 with a half-life period of 22 s generates the corresponding carbene.At the same time from 12 with ca. 20percent the yellow isomeric 4-(1-diazo-2,2,2-trifluoroethyl)benzoic acid (20) is formed which is photolyzed generating the same carbene as 12.The synthesis of 20 is described starting from 4-bromobenzaldehyde. - The diazirine 12 as its N-hydroxysuccinimide ester 13, or using other methods of amide synthesis, can readily be coupled to amino functions of biochemically interesting agents thus forming photoaffinity labels.