7572-74-9Relevant academic research and scientific papers
Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators
Pinkerton, Anthony B.,Sessions, E. Hampton,Hershberger, Paul,Maloney, Patrick R.,Peddibhotla, Satyamaheshwar,Hopf, Meghan,Sergienko, Eduard,Ma, Chen-Ting,Smith, Layton H.,Jackson, Michael R.,Tanaka, Jun,Tsuji, Takashi,Akiu, Mayuko,Cohen, Steven E.,Nakamura, Tsuyoshi,Gardell, Stephen J.
, (2021)
NAD+ is a crucial cellular factor that plays multifaceted roles in wide ranging biological processes. Low levels of NAD+ have been linked to numerous diseases including metabolic disorders, cardiovascular disease, neurodegeneration,
GLYT2 MODULATORS
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Page/Page column 114, (2010/02/11)
α-, β-, and γ-amino acid derivatives of formula I are disclosed as selective GlyT2 inhibitors for the treatment of central nervous system (CNS) conditions such as muscle spasticity, tinnitus, epilepsy and neuropathic pain. Formula I
