7146-68-1

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-chlorophenyl)sulfonylaniline is used as an active pharmaceutical ingredient (API) for its role as an Escherichia coli dihydropteroate synthase inhibitor. This application is significant because it helps in the development of drugs that target and inhibit the growth of E. coli bacteria, which is a common cause of various infections. By inhibiting the enzyme dihydropteroate synthase, 4-(4-chlorophenyl)sulfonylaniline can effectively disrupt the bacterial cell's synthesis of folic acid, thereby hindering their growth and proliferation.

InChI:InChI=1/C12H10ClNO2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,14H2

Upstream product

• 39055-84-0 1-chloro-4-((4-nitrophenyl)sulfonyl)benzene 
• 1948-92-1 4-(4-nitrophenylsulfonyl)aniline 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 89-64-5 p-chloro-o-nitrophenol 
• 106-54-7 p-Chlorothiophenol 
• 108-90-7 chlorobenzene 
• 21969-11-9 1-(4-chlorophenylthio)-4-nitrobenzene 
• 80-07-9 4,4'-dichlorodiphenyl sulphone 
• 7664-41-7 ammonia 
• 7758-99-8 copper(II) sulfate 
• 92426-21-6 [4-(4-chloro-benzenesulfonyl)-phenyl]-carbamic acid ethyl ester 
• 6630-10-0 acetic acid-[4-(4-chloro-benzenesulfonyl)-anilide] 

Downstream Products

• 54457-67-9 4'-Chlor-4-(3-propyl-ureido)-diphenylsulfon 
• 7572-74-9 [4-(4-chloro-benzenesulfonyl)-phenyl]-carbamic acid phenyl ester 
• 37924-26-8 4-(4-Chlorphenylsulfonyl)-trifluormethansulfonanilid 

Relevant academic research and scientific papers

Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators

NAD+ is a crucial cellular factor that plays multifaceted roles in wide ranging biological processes. Low levels of NAD+ have been linked to numerous diseases including metabolic disorders, cardiovascular disease, neurodegeneration,

ARYL-AND HETEROARYL-SUBSTITUTED BENZENE DERIVATIVES AS MODULATORS OF PI3-KINASE SIGNALLING PATHWAYS

The present disclosure relates to certain aryl- or heteroaryl-substituted benzene derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.