757245-81-1Relevant academic research and scientific papers
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands
Hong, Qingmei,Bakshi, Raman K.,Dellureficio, James,He, Shuwen,Ye, Zhixiong,Dobbelaar, Peter H.,Sebhat, Iyassu K.,Guo, Liangqin,Liu, Jian,Jian, Tianying,Tang, Rui,Kalyani, Rubana N.,MacNeil, Tanya,Vongs, Aurawan,Rosenblum, Charles I.,Weinberg, David H.,Peng, Qingping,Tamvakopoulos, Constantin,Miller, Randy R.,Stearns, Ralph A.,Cashen, Doreen,Martin, Willian J.,Chen, Airu S.,Metzger, Joseph M.,Chen, Howard Y.,Strack, Allison M.,Fong, Tung M.,MacLntyre, Euan,Van Der Ploeg, Lex H.T.,Wyvratt, Matthew J.,Nargund, Ravi P.
scheme or table, p. 4483 - 4486 (2010/10/02)
Design, syntheses and structure-activity relationships of N-acetylated piperazine privileged structures containing MC4R agonist compounds were described. The most potent derivatives were low nM MC4R selective full agonists. Several compounds from the series had modest pharmacokinetic properties.
ACYLATED PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS
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Page/Page column 61, (2010/11/26)
Certain novel 4 alkyl substituted N acylated piperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, cont
ACYLATED PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS
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Page 40, (2010/02/08)
Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention
